Title:
GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC TGFBR2
Document Type and Number:
WIPO Patent Application WO/2023/072081
Kind Code:
A1
Abstract:
Provided are genetically modified non-human animals that express a human or chimeric (e.g., humanized) TGFBR2, and methods of use thereof.
Inventors:
SUN XIAOXIA (CN)
ZHOU XIAOFEI (CN)
ZHOU XIAOFEI (CN)
Application Number:
PCT/CN2022/127401
Publication Date:
May 04, 2023
Filing Date:
October 25, 2022
Export Citation:
Assignee:
BIOCYTOGEN PHARMACEUTICALS BEIJING CO LTD (CN)
International Classes:
A01K67/027; C07K14/495
Domestic Patent References:
| WO2020223535A1 | 2020-11-05 | |||
| WO2020125639A1 | 2020-06-25 |
Other References:
DATABASE Nucleotide 23 December 2020 (2020-12-23), ANONYMOUS : "Homo sapiens transforming growth factor beta receptor 2 (TGFBR2), transcript variant 2, mRNA", XP093060078, retrieved from ncbi Database accession no. NM_003242.6
DATABASE Nucleotide 23 December 2020 (2020-12-23), ANONYMOUS : "Homo sapiens transforming growth factor beta receptor 2 (TGFBR2), transcript variant 1, mRNA", XP093060082, retrieved from ncbi Database accession no. NM_001024847.2
DATABASE Nucleotide 27 October 2020 (2020-10-27), ANONYMOUS : "Mus musculus transforming growth factor, beta receptor II (Tgfbr2), transcript variant 2, mRNA ", XP093060086, retrieved from ncbi Database accession no. NM_029575.3
DATABASE Nucleotide 27 October 2020 (2020-10-27), ANONYMOUS : "Mus musculus transforming growth factor, beta receptor II (Tgfbr2), transcript variant 1, mRNA", XP093060104, retrieved from ncbi Database accession no. NM_009371.3
DATABASE Nucleotide 23 April 2005 (2005-04-23), ANONYMOUS : "Mus musculus BAC clone RP24-318O6 from chromosome 9, complete sequence", XP093060112, retrieved from ncbi Database accession no. AC131777.2
DATABASE Nucleotide 23 December 2020 (2020-12-23), ANONYMOUS : "Homo sapiens transforming growth factor beta receptor 2 (TGFBR2), transcript variant 1, mRNA", XP093060082, retrieved from ncbi Database accession no. NM_001024847.2
DATABASE Nucleotide 27 October 2020 (2020-10-27), ANONYMOUS : "Mus musculus transforming growth factor, beta receptor II (Tgfbr2), transcript variant 2, mRNA ", XP093060086, retrieved from ncbi Database accession no. NM_029575.3
DATABASE Nucleotide 27 October 2020 (2020-10-27), ANONYMOUS : "Mus musculus transforming growth factor, beta receptor II (Tgfbr2), transcript variant 1, mRNA", XP093060104, retrieved from ncbi Database accession no. NM_009371.3
DATABASE Nucleotide 23 April 2005 (2005-04-23), ANONYMOUS : "Mus musculus BAC clone RP24-318O6 from chromosome 9, complete sequence", XP093060112, retrieved from ncbi Database accession no. AC131777.2
Attorney, Agent or Firm:
BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)
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