Title:
GENOME EDITING METHOD, COMPOSITION, CELL, CELL PREPARATION, AND METHOD FOR PRODUCING CELL PREPARATION
Document Type and Number:
WIPO Patent Application WO/2019/189573
Kind Code:
A1
Abstract:
A method for genome editing in an isolated cell, wherein the genome editing method is characterized in that foreign DNA having homology arms less than 500 bp in length is introduced into a target genome by homologous recombination of the 5' end and/or the 3' end of the foreign DNA.
Inventors:
HANAZONO YUTAKA (JP)
HARA HIROMASA (JP)
UOSAKI HIDEKI (JP)
HARA HIROMASA (JP)
UOSAKI HIDEKI (JP)
Application Number:
PCT/JP2019/013602
Publication Date:
October 03, 2019
Filing Date:
March 28, 2019
Export Citation:
Assignee:
UNIV JICHI MEDICAL (JP)
International Classes:
C12N15/09; A61K31/7088; A61K31/713; A61P37/04; C12N5/074; C12N5/10
Domestic Patent References:
| WO2016081923A2 | 2016-05-26 |
Foreign References:
| JP2018066174A | 2018-04-26 |
Other References:
ZHANG, JIANPING ET AL.: "Efficient precise knock in with a double cut HDR donor after CRISPR/Cas9- mediated double-stranded DNA cleavage", GENOME BIOLOGY, vol. 18, no. 35, 2017, pages 1 - 18, XP055399694
MORGAN, A. RICHARD ET AL.: "Hematopoietic Stem Cell Gene Therapy: Progress and Lessons Learned", CELL STEM CELL, vol. 21, 2017, pages 574 - 590, XP085274783, doi:10.1016/j.stem.2017.10.010
NATURE, vol. 539, no. 7629, 17 November 2016 (2016-11-17), pages 384 - 389
SCI REP., vol. 7, 2017, pages 8943
NAT BIOTECHNOL., vol. 33, no. 5, May 2015 (2015-05-01), pages 543 - 548
NAT BIOTECHNOL., vol. 34, 2016, pages 339 - 344
WATANABE M ET AL., PLOS ONE., vol. 8, no. 10, 9 October 2013 (2013-10-09), pages e76478
See also references of EP 3778888A4
MORGAN, A. RICHARD ET AL.: "Hematopoietic Stem Cell Gene Therapy: Progress and Lessons Learned", CELL STEM CELL, vol. 21, 2017, pages 574 - 590, XP085274783, doi:10.1016/j.stem.2017.10.010
NATURE, vol. 539, no. 7629, 17 November 2016 (2016-11-17), pages 384 - 389
SCI REP., vol. 7, 2017, pages 8943
NAT BIOTECHNOL., vol. 33, no. 5, May 2015 (2015-05-01), pages 543 - 548
NAT BIOTECHNOL., vol. 34, 2016, pages 339 - 344
WATANABE M ET AL., PLOS ONE., vol. 8, no. 10, 9 October 2013 (2013-10-09), pages e76478
See also references of EP 3778888A4
Attorney, Agent or Firm:
TANAI Sumio et al. (JP)
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