Title:
GLUTAMATE DECARBOXYLASE MUTANT AND USE IN PRODUCTION OF γ-AMINOBUTYRIC ACID
Document Type and Number:
WIPO Patent Application WO/2023/240871
Kind Code:
A1
Abstract:
Provided are a glutamate decarboxylase mutant and the use in the production of γ-aminobutyric acid. Further provided are an improved recombinant Corynebacterium glutamicum and a biosensor capable of responding to γ-aminobutyric acid.
Inventors:
ZHU LINGFENG (CN)
CHEN YUFEI (CN)
ZHAO CHANGLE (CN)
LUO XIAOZHOU (CN)
CHEN YUFEI (CN)
ZHAO CHANGLE (CN)
LUO XIAOZHOU (CN)
Application Number:
PCT/CN2022/126883
Publication Date:
December 21, 2023
Filing Date:
October 24, 2022
Export Citation:
Assignee:
SYNCERES BIOSCIENCES SHENZHEN CO LTD (CN)
SHENZHEN INSTITUTE OF ADVANCED TECH CHINESE ACADEMY OF SCIENCE (CN)
SHENZHEN INSTITUTE OF ADVANCED TECH CHINESE ACADEMY OF SCIENCE (CN)
International Classes:
C12N9/88; C12N1/21; C12N15/60; C12N15/65; C12N15/77; C12P13/00; C12R1/15
Foreign References:
| CN114752589A | 2022-07-15 | |||
| CN114752544A | 2022-07-15 | |||
| CN102154393A | 2011-08-17 | |||
| CN108467860A | 2018-08-31 | |||
| CN109722402A | 2019-05-07 | |||
| CN111635898A | 2020-09-08 | |||
| CN112251428A | 2021-01-22 | |||
| US20200399632A1 | 2020-12-24 |
Other References:
LIU QINGDAI; CHENG HAIJIAO; MA XIAOQIAN; XU NING; LIU JUN; MA YANHE: "Expression, characterization and mutagenesis of a novel glutamate decarboxylase fromBacillus megaterium", BIOTECHNOLOGY LETTERS, KLUWER ACADEMIC PUBLISHERS, DORDRECHT, vol. 38, no. 7, 8 March 2016 (2016-03-08), Dordrecht , pages 1107 - 1113, XP035901451, ISSN: 0141-5492, DOI: 10.1007/s10529-016-2070-y
NARDELLA CATERINA, BARILE ANNA, DI SALVO MARTINO L., MILANO TERESA, PASCARELLA STEFANO, TRAMONTI ANGELA, CONTESTABILE ROBERTO: "Interaction of Bacillus subtilis GabR with the gabTD promoter: role of repeated sequences and effect of GABA in transcriptional activation", THE FEBS JOURNAL, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 287, no. 22, 1 November 2020 (2020-11-01), GB , pages 4952 - 4970, XP093117526, ISSN: 1742-464X, DOI: 10.1111/febs.15286
CHENG, HAIJIAO: "The Study on Enzyme Characterization of Glutamate Decarboxylase from Bacillus megaterium", CHINA MASTER’S THESES FULL-TEXT DATABASE (BASIC SCIENCES), 15 May 2020 (2020-05-15)
NARDELLA CATERINA, BARILE ANNA, DI SALVO MARTINO L., MILANO TERESA, PASCARELLA STEFANO, TRAMONTI ANGELA, CONTESTABILE ROBERTO: "Interaction of Bacillus subtilis GabR with the gabTD promoter: role of repeated sequences and effect of GABA in transcriptional activation", THE FEBS JOURNAL, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 287, no. 22, 1 November 2020 (2020-11-01), GB , pages 4952 - 4970, XP093117526, ISSN: 1742-464X, DOI: 10.1111/febs.15286
CHENG, HAIJIAO: "The Study on Enzyme Characterization of Glutamate Decarboxylase from Bacillus megaterium", CHINA MASTER’S THESES FULL-TEXT DATABASE (BASIC SCIENCES), 15 May 2020 (2020-05-15)
Attorney, Agent or Firm:
HARBIN SHINEIP INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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