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Title:
GLYCOSYLATED POLYPEPTIDE AND DRUG COMPOSITION CONTAINING SAID POLYPEPTIDE
Document Type and Number:
WIPO Patent Application WO/2013/032011
Kind Code:
A1
Abstract:
[Problem] To provide a glycosylated polypeptide having an affinity to somatostatin receptors, and, compared to somatostatins, having improved in-blood stability. [Solution] The glycosylated polypeptide is characterized by at least one amino acid in a somatostatin or an analogue thereof being replaced with a glycosylated amino acid.

Inventors:
OCHIAI HIROFUMI (JP)
SHIMODA TAIJI (JP)
FUKAE KAZUHIRO (JP)
MAEDA MASATOSHI (JP)
ISHII KAZUYUKI (JP)
YOSHIDA KENTA (JP)
TEZUKA KATSUNARI (JP)
TAZURU KEISUKE (JP)
Application Number:
PCT/JP2012/072380
Publication Date:
March 07, 2013
Filing Date:
September 03, 2012
Export Citation:
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Assignee:
GLYTECH INC (JP)
OCHIAI HIROFUMI (JP)
SHIMODA TAIJI (JP)
FUKAE KAZUHIRO (JP)
MAEDA MASATOSHI (JP)
ISHII KAZUYUKI (JP)
YOSHIDA KENTA (JP)
TEZUKA KATSUNARI (JP)
TAZURU KEISUKE (JP)
International Classes:
C07K14/655; A61K38/00; A61K47/48; A61P1/00; A61P1/04; A61P1/12; A61P3/10; A61P5/02; A61P19/02; A61P25/04; A61P25/28; A61P27/02; A61P27/06; A61P27/12; A61P29/00; A61P35/00; A61P43/00; C07K2/00; C07K19/00
Domestic Patent References:
WO2009156511A22009-12-30
WO2009153960A12009-12-23
WO2004005330A12004-01-15
WO2005010053A12005-02-03
WO2003008431A12003-01-30
WO2004058984A12004-07-15
WO2004058824A12004-07-15
WO2004070046A12004-08-19
WO2007011055A12007-01-25
Foreign References:
JPH11514363A1999-12-07
US4310518A1982-01-12
US4235886A1980-11-25
JPH0314599A1991-01-23
US20050222382A12005-10-06
US20070060543A12007-03-15
US20040181054A12004-09-16
US20060228784A12006-10-12
US20060009421A12006-01-12
US20060205039A12006-09-14
Other References:
HARUHIKO SAITO: "Atarashii Somatostatin Analog no Rinsho Oyo", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 141, no. 12, 1987, pages 907 - 909, XP008172639
NISHI T. ET AL.: "Tosa Kogaku ni yoru Iryo-yo Tanpakushitsu no Shitsuteki Kaizen", TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, vol. 4, no. 18, 1992, pages 336 - 344, XP008172756
PRADAYROL L. ET AL.: "N-terminally extended somatostatin: the primary structure of somatostatin-28", FEBS LETT., vol. 109, no. 1, 1980, pages 55 - 58, XP025615438
CURRRENT OPINION IN PHARMACOLOGY, vol. 4, 2004, pages 608 - 613
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MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 286, 2008, pages 69 - 74
J. MED. CHEM., vol. 44, 2001, pages 2238 - 2246
ENDOCRINOLOGY, vol. 10, 1982, pages 1049 - 1051
FEBS LETTERS, vol. 50, no. 3, February 1975 (1975-02-01)
CHENG, Y ET AL., BIOCHEM PHARMACOL, vol. 22, 1973, pages 3099 - 3108
"Japanese Pharmacopeia saline", OTSUKA PHARMACEUTICAL FACTORY, INC.
SCAND. J. GASTROENTEROL., vol. 30, no. 5, May 1995 (1995-05-01), pages 464 - 9
J HISTOCHEM CYTOCHEM., vol. 52, no. 3, March 2004 (2004-03-01), pages 391 - 400
See also references of EP 2752424A4
Attorney, Agent or Firm:
NANJO, Masahiro et al. (JP)
Masahiro Nanjo (JP)
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