HETEROCYCLIC CONTAINING BIPHENYL aP2 INHIBITORS AND METHOD

Title:

HETEROCYCLIC CONTAINING BIPHENYL aP2 INHIBITORS AND METHOD

Document Type and Number:

WIPO Patent Application WO2000059506

Kind Code:

A8

Abstract:

aP2 inhibiting compounds are provided having formula (I) wherein R<1>, R<2>, R<3>, R<4>, X-Z and (a) are as described herein. A method is also provided for treating diabetes and related diseases, especially Type II diabetes, employing such aP2 inhibitor or a combination of such aP2 inhibitor and another antidiabetic agent such as metformin, glyburide, troglitazone and/or insulin.

Inventors:

ROBL JEFFREY A
SULSKY RICHARD B
MAGNIN DAVID R

Application Number:

PCT/US2000/007417

Publication Date:

March 08, 2001

Filing Date:

March 20, 2000

Export Citation:

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Assignee:

BRISTOL MYERS SQUIBB CO (US)

International Classes:

A61K31/341; A61K31/357; A61K31/381; A61K31/41; A61K31/415; A61K31/4164; A61K31/4178; A61K31/4196; A61K31/421; A61K31/422; A61K31/444; A61K45/00; A61K45/06; A61P1/00; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P11/00; A61P19/02; A61P37/06; A61P43/00; C07D207/323; C07D207/333; C07D207/444; C07D207/452; C07D231/12; C07D231/22; C07D233/54; C07D233/56; C07D233/60; C07D233/64; C07D233/68; C07D249/12; C07D263/32; C07D307/12; C07D307/42; C07D317/22; C07D333/20; C07D403/10; C07D403/12; C07D405/10; C07D405/12; C07D413/10; C07D413/12; C07D413/14; C07D207/32; C07D207/44; (IPC1-7): A61K31/41; A61K31/4164; A61K31/4178; A61K31/4196; A61K31/4245; C07D233/54; C07D233/56; C07D233/60; C07D233/68; C07D249/12; C07D257/10; C07D263/30; C07D263/34; C07D403/00

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