Title:
INHIBITORS FOR VASCULAR RECONSTRICTION AFTER ANGIOPLASTY
Document Type and Number:
WIPO Patent Application WO/2000/059505
Kind Code:
A1
Abstract:
Novel medicinal compositions to be used in phtochemotherapy whereby vascular reconstriction after percutaneous transluminal coronary recanalization or percutaneous transluminal angioplasty can be inhibited which contain as the active ingredient mono-L-aspartylchlorin e6 or mono-L-glutamylchlorin e6 or salts thereof; and a photodynamic therapy method for inhibiting vascular reconstriction after angioplasty by using these compositions.
Inventors:
NAGAE TSUNEYUKI (JP)
AIZAWA KATSUO (JP)
AIZAWA KATSUO (JP)
Application Number:
PCT/JP2000/002156
Publication Date:
October 12, 2000
Filing Date:
April 03, 2000
Export Citation:
Assignee:
MEIJI SEIKA KAISHA (JP)
NAGAE TSUNEYUKI (JP)
AIZAWA KATSUO (JP)
NAGAE TSUNEYUKI (JP)
AIZAWA KATSUO (JP)
International Classes:
A61K31/409; A61K41/00; A61P9/00; C07D487/22; (IPC1-7): A61K31/409; A61P9/00
Domestic Patent References:
| WO1995003797A1 | 1995-02-09 |
Foreign References:
| US5308861A | 1994-05-03 |
Other References:
WILLIAM D. COATS JR. ET AL: "Tin ethyl etiopurpurin signifinanctly inhibits vascular smooth muscle cell proliferation in vivo", BIOCHEMISTRY AND CELL BIOLOGY, vol. 74, no. 3, 1996, pages 325 - 331, XP002927497
P.C. DARTSCH, ET AL: "Photodynamic therapy of vascular stenoses? Response of cultured human smooth muscle cells from non-atherosclerotic arteries and atheromatous plaques following treatment with photosensitizing porphyrins", PROCEEDINGS. SPIE-THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING, vol. 1462, 1990, pages 77 - 80, XP002927498
PETER C. DARTSCH ET AL: "Responses of cultured smooth muscle cells from human nonatherosclerotic arteries and primary stenosing lesions after photoradiation: implications for photodynamic therapy of vascular stenoses", JOURNAL OF THE AMERICAN COLLEGE CARDIOLOGY, vol. 15, 1990, pages 1545 - 1550, XP002927499
KAZUO UMEMURA: "PTCA go no sai sakushu: Yakubutsu chiryou no kanousei", KEKKAN TO NAIHI, vol. 6, no. 1, 1996, pages 56 - 64, XP002935469
P.C. DARTSCH, ET AL: "Photodynamic therapy of vascular stenoses? Response of cultured human smooth muscle cells from non-atherosclerotic arteries and atheromatous plaques following treatment with photosensitizing porphyrins", PROCEEDINGS. SPIE-THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING, vol. 1462, 1990, pages 77 - 80, XP002927498
PETER C. DARTSCH ET AL: "Responses of cultured smooth muscle cells from human nonatherosclerotic arteries and primary stenosing lesions after photoradiation: implications for photodynamic therapy of vascular stenoses", JOURNAL OF THE AMERICAN COLLEGE CARDIOLOGY, vol. 15, 1990, pages 1545 - 1550, XP002927499
KAZUO UMEMURA: "PTCA go no sai sakushu: Yakubutsu chiryou no kanousei", KEKKAN TO NAIHI, vol. 6, no. 1, 1996, pages 56 - 64, XP002935469
Attorney, Agent or Firm:
Yagita, Shigeru (Nishi Shimbashi 1-chome Minato-ku Tokyo, JP)
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