Title:
HETERODIMERIC FOLLICLE STIMULATING HORMONE-Fc (FSH-Fc) FUSION PROTEINS FOR THE TREATMENT OF INFERTILITY
Document Type and Number:
WIPO Patent Application WO2005073383
Kind Code:
A3
Abstract:
The invention provides novel heterodimeric fusion proteins comprising a first polypeptide including an alpha subunit of FSH (aFSH) linked directly or indirectly to a binding partner of neonatal Fc receptor (FcRn) and a second polypeptide including a beta subunit of FSH (ßFSH) linked directly or indirectly to an FcRn binding partner. In one embodiment the FcRn binding partner includes an Fc fragment of an immunoglobulin, e.g., an Fc fragment of IgG. Also provided are methods making and using the fusion proteins of the invention. The invention provides a method for increasing fertility in a subject and a method for treating a subject having a disease state responsive to treatment by FSH.
Inventors:
LOW SUSAN C (US)
Application Number:
PCT/US2005/003034
Publication Date:
November 24, 2005
Filing Date:
January 27, 2005
Export Citation:
Assignee:
SYNTONIX PHARMACEUTICALS INC (US)
LOW SUSAN C (US)
LOW SUSAN C (US)
International Classes:
C07H21/04; C07K14/59; C07K16/46; C12N15/62; A61K38/00; (IPC1-7): C12N15/62; C07K14/59; C07K16/46
Domestic Patent References:
| WO2004004798A2 | 2004-01-15 |
Foreign References:
| US5767251A | 1998-06-16 |
Other References:
BOULOUX P M G ET AL: "FIRST HUMAN EXPOSURE TO FSH-CTP IN HYPOGONADOTROPHIC HYPOGONADAL MALES", HUMAN REPRODUCTION, IRL PRESS, OXFORD, GB, vol. 16, no. 8, August 2001 (2001-08-01), pages 1592 - 1597, XP001080293, ISSN: 0268-1161
SUGAHARA TADASHI ET AL: "Expression of biologically active fusion genes encoding the common alpha subunit and the follicle-stimulating hormone beta subunit: Role of a Linker sequence", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 18, 1996, pages 10445 - 10448, XP002341640, ISSN: 0021-9258
SUGAHARA TADASHI ET AL: "Expression of biologically active fusion genes encoding the common alpha subunit and the follicle-stimulating hormone beta subunit: Role of a Linker sequence", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 18, 1996, pages 10445 - 10448, XP002341640, ISSN: 0021-9258
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