HEPATITIS C VIRUS SUB-GENOMIC REPLICONS

WIPO Patent Application WO2003085084

A3

The present invention relates generally to the construction of sub-genomic HCV replicon systems that may provide the foundation for generating HCV replicons of all six major genotypes and subtypes to facilitate screening, testing, and evaluating anti-infective agents for HCV disease(s).

JP3844494	Peptide that induces cytotoxic T lymphocyte response to hepatitis C virus
JP2641688	[Title of Invention] A method for producing a protein using a herpes virus vector.
WO/2005/113837	TRUNCATED HEPATITIS C VIRUS NS5 DOMAIN AND FUSION PROTEINS COMPRISING SAME

GATES ADAM (US)
GU BAOHUA (US)
SARISKY ROBERT T (US)

PCT/US2003/010177

July 22, 2004

April 03, 2003

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SMITHKLINE BEECHAM CORP (US)
GATES ADAM (US)
GU BAOHUA (US)
SARISKY ROBERT T (US)

C07K14/18; C12N7/00; C12N15/86; C12Q1/70; (IPC1-7): C07H21/04

US20010034019A1	2001-10-25
US6326137B1	2001-12-04
EP1043399A2	2000-10-11

LOHMANN V. ET AL.: "Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line", SCIENCE, vol. 285, no. 5424, 2 July 1999 (1999-07-02), pages 110 - 113, XP000960693
BARTENSCHLAGER R., LOHMANN V.: "Replication of hepatitis C virus", JOURNAL OF GENERAL VIROLOGY, vol. 81, no. 7, July 2000 (2000-07-01), pages 1631 - 1648, XP000982017
LOHMANN V. ET AL.: "Mutations in hepatitis C virus RNAs conferring cell culture adaptation", JOURNAL OF VIROLOGY, vol. 75, no. 3, February 2001 (2001-02-01), pages 1437 - 1449, XP001029115
FRIEBE P. ET AL.: "Sequences in the 5' nontranslated region of hepatitis C virus required for RNA replication", JOURNAL OF VIROLOGY, vol. 75, no. 24, December 2001 (2001-12-01), pages 12047 - 12057, XP002977108
See also references of EP 1490389A4

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