Title:
HEPTAMETHINE CYANINE DYE-ARTEMISININ CONJUGATE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/045414
Kind Code:
A1
Abstract:
The present invention provides a heptamethine cyanine dye-artemisinin conjugate and use thereof, and belongs to the technical field of cancer therapy. The heptamethine cyanine dye-artemisinin conjugate provided by the present invention can induce rapid apoptosis of prostate cancer and breast cancer cells within 24 hours, has the effect of inhibiting tumor growth, and has the effect of reducing cancer cell survival that is significantly superior to that of a positive drug, docetaxel. In addition, the heptamethine cyanine dye-artemisinin conjugate of the present invention also has significant anti-cancer and cancer-inhibitory effects on tumor cells with drug resistance to enzalutamide, abiraterone, and paclitaxel.
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Inventors:
ZHAU HAIYEN (CN)
YU BO (CN)
CHENG YUPING (CN)
LIAO KAI (CN)
YU BO (CN)
CHENG YUPING (CN)
LIAO KAI (CN)
Application Number:
PCT/CN2022/139240
Publication Date:
March 07, 2024
Filing Date:
December 15, 2022
Export Citation:
Assignee:
DEZHEN CHINA MEDICAL TECH CO LTD (CN)
International Classes:
A61K47/54; A61K31/366; A61P35/00
Foreign References:
| CN110563743A | 2019-12-13 | |||
| CN110590638A | 2019-12-20 |
Attorney, Agent or Firm:
BEIJING GAOWO LAW FIRM (CN)
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