Title:
HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING PHENYLENEDIAMINE GROUP
Document Type and Number:
WIPO Patent Application WO2000034258
Kind Code:
A3
Abstract:
Compounds having formula (I) wherein R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, CN, NO2, CO2R6, COR6, OR6, SR6, SOR6, SO2R6, CONR7R8, NR6N(R7R8), N(R7R8) or W-Y-(CH2)n-Z provided that at least one of R1-R5 is not hydrogen; or R2 and R3 or R3 and R4, taken together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R7 and R8, taken together may form a 3 to 7 membered heterocycloalkyl; W is O, NR6, or is absent; Y is (CO)- or (CO2)-, or is absent; Z is alkyl of 1 to 4 carbon atoms, CN, CO2R6, COR6, CONR7R8, OCOR6, NR6COR7, OCONR6, OR6, SR6, SOR6, SO2R6, SR6N(R7R8), N(R7R8) or phenyl; G is monocyclic heteroaryl; X is a bond, NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, or thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6, useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses -6 and -7, and Kaposi herpesvirus.
Inventors:
BLOOM JONATHAN DAVID
CURRAN KEVIN JOSEPH
DIGRANDI MARTIN JOSEPH
DUSHIN RUSSELL GEORGE
JONES THOMAS RICHARD
LANG STANLEY ALBERT
ROSS ADMA ANTONIA
TEREFENKO EUGENE ANTHONY
O'HARA BRYAN MARK
CURRAN KEVIN JOSEPH
DIGRANDI MARTIN JOSEPH
DUSHIN RUSSELL GEORGE
JONES THOMAS RICHARD
LANG STANLEY ALBERT
ROSS ADMA ANTONIA
TEREFENKO EUGENE ANTHONY
O'HARA BRYAN MARK
Application Number:
PCT/US1999/028842
Publication Date:
November 29, 2001
Filing Date:
December 06, 1999
Export Citation:
Assignee:
AMERICAN HOME PROD (US)
International Classes:
A61K31/341; A61K31/4164; A61K31/421; A61K31/426; A61K31/433; A61P7/00; A61P11/00; A61P17/00; A61P25/00; A61P27/02; A61P31/18; A61P31/22; C07D233/90; C07D263/34; C07D277/20; C07D277/56; C07D285/06; C07D307/68; C07D417/12; (IPC1-7): C07D285/06; C07D277/56; C07D307/68; C07D263/34; C07D233/90; A61K31/433; A61K31/426; A61K31/341; A61K31/421; A61K31/4164; A61P31/22
Domestic Patent References:
| WO1998045259A2 | 1998-10-15 |
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