Title:
HETEROCYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/095569
Kind Code:
A1
Abstract:
Disclosed are a heterocyclic compound for an immune checkpoint inhibitor capable of blocking a VISTA signaling pathway, and a preparation method therefor and a use thereof. The compound is as represented by formula I. The compound has a novel structure, can be formulated for oral administration, overcomes the treatment defects and drug resistance of monoclonal antibody-based immune checkpoint inhibitors, can be used to prepare a small molecule inhibitor easily, and is convenient for industrial production.
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Inventors:
JIANG SHENG (CN)
XIAO YIBEI (CN)
WANG TIANYU (CN)
ZHANG YU (CN)
HAO HAIPING (CN)
WANG MINMIN (CN)
ZHANG KUOJUN (CN)
QIU YATAO (CN)
XIAO YIBEI (CN)
WANG TIANYU (CN)
ZHANG YU (CN)
HAO HAIPING (CN)
WANG MINMIN (CN)
ZHANG KUOJUN (CN)
QIU YATAO (CN)
Application Number:
PCT/CN2021/115172
Publication Date:
May 12, 2022
Filing Date:
August 27, 2021
Export Citation:
Assignee:
YAOKANG ZHONGTUO JIANGSU PHARMACEUTICAL TECH CO LTD (CN)
International Classes:
C07D235/18; A61K31/4184; A61K31/4188; A61K31/423; A61K31/428; A61K31/4355; A61K31/437; A61K31/4439; A61K31/454; A61K31/5025; A61K31/519; A61P35/00; A61P37/06; C07D263/57; C07D277/66; C07D401/10; C07D401/12; C07D403/10; C07D403/12; C07D405/04; C07D471/04; C07D487/04; C07D491/048; C07D491/056
Domestic Patent References:
| WO1998006703A1 | 1998-02-19 | |||
| WO2001027088A1 | 2001-04-19 |
Foreign References:
| CN112321513A | 2021-02-05 | |||
| CN109081813A | 2018-12-25 | |||
| CN104151250A | 2014-11-19 | |||
| CN111875796A | 2020-11-03 | |||
| CN103282034A | 2013-09-04 | |||
| CN102236259A | 2011-11-09 |
Other References:
ABUZAR SYED, SATYAVAN SHARMA: "Synthesis of Substituted Benzimidazoles as Potential Anthelminthics", ARCHIV DER PHARMAZIE, WILEY VERLAG, WEINHEIM, vol. 315, no. 10, 31 December 1982 (1982-12-31), Weinheim , pages 866 - 871, XP055927618, ISSN: 0365-6233, DOI: 10.1002/ardp.19823151009
XIE ZEQIANG, FENGTAO ZHOU, KE DING: "Copper-Mediated Diamination of Arylboronic Acids for the Synthesis of 2-Aryl Benzimidazoles Using Trimethylsilyl Azide as the Amino Sources with Aldehydes", ADVANCED SYNTHESIS AND CATALYSIS, vol. 362, no. 16, 24 July 2020 (2020-07-24), pages 3442 - 3446, XP055927620, ISSN: 1615-4150, DOI: 10.1002/adsc.202000385
XU CHEN, ZHI-QIANG XIAO, HONG-MEI LI, XIN HAN, ZHI-QIANG WANG, WEI-JUN FU, BAO-MING JI, XIN-QI HAO, MAO-PING SONG: "Ligand-Free Pd/C-Catalyzed One-Pot, Three-Component Synthesis of Aryl-Substituted Benzimidazoles by Hydrogen-Transfer and Suzuki Reactions in Water", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2015, no. 34, 3 November 2015 (2015-11-03), pages 7427 - 7432, XP055927624, ISSN: 1099-0690, DOI: 10.1002/ejoc.201501169
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XIE ZEQIANG, FENGTAO ZHOU, KE DING: "Copper-Mediated Diamination of Arylboronic Acids for the Synthesis of 2-Aryl Benzimidazoles Using Trimethylsilyl Azide as the Amino Sources with Aldehydes", ADVANCED SYNTHESIS AND CATALYSIS, vol. 362, no. 16, 24 July 2020 (2020-07-24), pages 3442 - 3446, XP055927620, ISSN: 1615-4150, DOI: 10.1002/adsc.202000385
XU CHEN, ZHI-QIANG XIAO, HONG-MEI LI, XIN HAN, ZHI-QIANG WANG, WEI-JUN FU, BAO-MING JI, XIN-QI HAO, MAO-PING SONG: "Ligand-Free Pd/C-Catalyzed One-Pot, Three-Component Synthesis of Aryl-Substituted Benzimidazoles by Hydrogen-Transfer and Suzuki Reactions in Water", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2015, no. 34, 3 November 2015 (2015-11-03), pages 7427 - 7432, XP055927624, ISSN: 1099-0690, DOI: 10.1002/ejoc.201501169
RANGARAJAN MEERA; KIM JUNG SUN; JIN SONG; SIM SAI-PENG; LIU ANGELA; PILCH DANIEL S.; LIU LEROY F.; LAVOIE EDMOND J.: "2″-Substituted 5-phenylterbenzimidazoles as topoisomerase I poisons", BIOORGANIC, ELSEVIER, AMSTERDAM, NL, vol. 8, no. 6, 5 June 2017 (2017-06-05), AMSTERDAM, NL, pages 1371 - 1382, XP085050454, ISSN: 0968-0896, DOI: 10.1016/S0968-0896(00)00054-7
Attorney, Agent or Firm:
BEIJING JUNYOU INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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