Title:
HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2019/189553
Kind Code:
A1
Abstract:
The present invention provides a heterocyclic compound having an activity to enhance the maturation of a cardiomyocyte. A compound represented by formula (I) [wherein each symbol is as defined in the description] or a salt thereof has an activity to enhance the maturation of a cardiomyocyte and is therefore useful as a cardiomyocyte maturation enhancer.
Inventors:
YOSHIDA YOSHINORI (JP)
MIKI KENJI (JP)
KAIEDA AKIRA (JP)
KONDO SHIGERU (JP)
NARA HIROSHI (JP)
IKEURA YOSHINORI (JP)
MIKI KENJI (JP)
KAIEDA AKIRA (JP)
KONDO SHIGERU (JP)
NARA HIROSHI (JP)
IKEURA YOSHINORI (JP)
Application Number:
PCT/JP2019/013529
Publication Date:
October 03, 2019
Filing Date:
March 28, 2019
Export Citation:
Assignee:
UNIV KYOTO (JP)
TAKEDA PHARMACEUTICALS CO (JP)
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
C07D401/14; C07D403/04; C07D403/14; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C12N5/077
Domestic Patent References:
| WO2015182765A1 | 2015-12-03 | |||
| WO2012026491A1 | 2012-03-01 | |||
| WO2007002136A2 | 2007-01-04 | |||
| WO2009118928A1 | 2009-10-01 | |||
| WO2007069666A1 | 2007-06-21 | |||
| WO2008118220A2 | 2008-10-02 | |||
| WO2008124133A1 | 2008-10-16 | |||
| WO2008151058A2 | 2008-12-11 | |||
| WO2009006930A1 | 2009-01-15 | |||
| WO2009006997A1 | 2009-01-15 | |||
| WO2009007852A2 | 2009-01-15 | |||
| WO2005033298A1 | 2005-04-14 | |||
| WO2007126077A1 | 2007-11-08 | |||
| WO2012133945A1 | 2012-10-04 | |||
| WO2013137491A1 | 2013-09-19 | |||
| WO2014192909A1 | 2014-12-04 | |||
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Foreign References:
| JP2016521571A | 2016-07-25 | |||
| JP2017060422A | 2017-03-30 | |||
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| JP2018069872A | 2018-03-30 |
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LAFLAMME MA ET AL., NAT BIOTECHNOL, vol. 25, 2007, pages 1015 - 1024
KIM JB.SCHOLER HR. ET AL., NATURE, vol. 454, 2008, pages 646 - 650
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J. A. THOMSON ET AL., SCIENCE, vol. 282, 1998, pages 1145 - 1147
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J. A. THOMSON ET AL., BIOL. REPROD., vol. 55, 1996, pages 254 - 259
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H. SUEMORI ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 345, 2006, pages 926 - 932
M. UENO ET AL., PROC. NATL. ACAD. SCI., vol. 103, 2006, pages 9554 - 9559
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H. KAWASAKI ET AL., PROC. NATL. ACAD. SCI., vol. 99, 2002, pages 1580 - 1585
KLIMANSKAYA I ET AL., NATURE, vol. 444, 2006, pages 481 - 485
0. FUMITAKA ET AL., NAT. BIOTECHNOL., vol. 26, 2008, pages 443 - 452
M. KANATSU-SHINOHARA ET AL., BIOL. REPROD., vol. 69, 2003, pages 612 - 616
HUANGFU D.MELTON, DA. ET AL., NATURE BIOTECHNOLOGY, vol. 26, no. 7, 2008, pages 795 - 797
Y. MATSUI ET AL., CELL, vol. 70, 1992, pages 841 - 847
J. L. RESNICK ET AL., NATURE, vol. 359, 1992, pages 550 - 551
TAKAHASHI KYAMANAKA S., CELL, vol. 126, 2006, pages 663 - 676
OKITA, K.ICHISAKA, T.YAMANAKA, S., NATURE, vol. 450, 2007, pages 497 - 502
OKITA K ET AL., NAT. METHODS, vol. 8, no. 5, May 2011 (2011-05-01), pages 409 - 12
OKITA K ET AL., STEM CELLS., vol. 31, no. 3, pages 458 - 66
YU J.THOMSON JA. ET AL., SCIENCE, vol. 318, 2007, pages 1917 - 1920
SHI Y.DING S. ET AL., CELL STEM CELL, vol. 3, no. 5, 2008, pages 568 - 574
T. WAKAYAMA ET AL., SCIENCE, vol. 292, 2001, pages 740 - 743
S. WAKAYAMA ET AL., BIOL. REPROD., vol. 72, 2005, pages 932 - 936
J.B. CIBELLI ET AL., NATURE BIOTECHNOL., vol. 16, 1998, pages 642 - 646
SAYAKA WAKAYAMA ET AL., EXPERIMENTAL MEDICINE, vol. 26, no. 5, 2008, pages 47 - 52
LAFLAMME MAMURRY CE, NATURE, 2011
YANG L ET AL.: "Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population.", NATURE, vol. 453, no. 7194, 22 May 2008 (2008-05-22), pages 524 - 8, XP002561095, DOI: 10.1038/nature06894
LIAN X ET AL.: "Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling", PROC NATL ACAD SCI, vol. 109, no. 27, 3 July 2012 (2012-07-03), pages E1848 - 57, XP055053519, DOI: 10.1073/pnas.1200250109
MINAMI I ET AL.: "A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions", CELL REP., vol. 2, no. 5, 29 November 2012 (2012-11-29), pages 1448 - 60, XP055097336, DOI: 10.1016/j.celrep.2012.09.015
OKITA K ET AL., STEM CELLS, 29 November 2012 (2012-11-29)
OKITA ET AL., NAT METHODS, vol. 8, no. 5, 2011, pages 409 - 12
NAKAGAWA M ET AL., NAT BIOTECHNOL., vol. 26, 2008, pages 101 - 6
DUBOIS NC ET AL., NAT BIOTECHNOL., vol. 29, 2011, pages 1011 - 8
See also references of EP 3778587A4
LAFLAMME MA ET AL., NAT BIOTECHNOL, vol. 25, 2007, pages 1015 - 1024
KIM JB.SCHOLER HR. ET AL., NATURE, vol. 454, 2008, pages 646 - 650
STRATEGIC APPLICATIONS OF NAMED REACTIONS IN ORGANIC SYNTHESIS, vol. 1, 14
"Comprehensive Organic Transformations", 1989, VCH PUBLISHERS INC.
TAKAHASHI KYAMANAKA S. ET AL., CELL, vol. 131, 2007, pages 861 - 872
K. SHINOHARA ET AL., CELL, vol. 119, 2004, pages 1001 - 1012
M. J. EVANSM. H. KAUFMAN, NATURE, vol. 292, 1981, pages 154 - 156
J. A. THOMSON ET AL., SCIENCE, vol. 282, 1998, pages 1145 - 1147
J. A. THOMSON ET AL., PROC. NATL. ACAD. SCI., vol. 92, 1995, pages 7844 - 7848
J. A. THOMSON ET AL., BIOL. REPROD., vol. 55, 1996, pages 254 - 259
J. A. THOMSONV. S. MARSHALL, CURR. TOP. DEV. BIOL., vol. 38, 1998, pages 133 - 165
THOMSON JA ET AL., PROC NATL. ACAD. SCI., vol. 92, 1995, pages 7844 - 7848
H. SUEMORI ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 345, 2006, pages 926 - 932
M. UENO ET AL., PROC. NATL. ACAD. SCI., vol. 103, 2006, pages 9554 - 9559
H. SUEMORI ET AL., DEV. DYN., vol. 222, 2001, pages 273 - 279
H. KAWASAKI ET AL., PROC. NATL. ACAD. SCI., vol. 99, 2002, pages 1580 - 1585
KLIMANSKAYA I ET AL., NATURE, vol. 444, 2006, pages 481 - 485
0. FUMITAKA ET AL., NAT. BIOTECHNOL., vol. 26, 2008, pages 443 - 452
M. KANATSU-SHINOHARA ET AL., BIOL. REPROD., vol. 69, 2003, pages 612 - 616
HUANGFU D.MELTON, DA. ET AL., NATURE BIOTECHNOLOGY, vol. 26, no. 7, 2008, pages 795 - 797
Y. MATSUI ET AL., CELL, vol. 70, 1992, pages 841 - 847
J. L. RESNICK ET AL., NATURE, vol. 359, 1992, pages 550 - 551
TAKAHASHI KYAMANAKA S., CELL, vol. 126, 2006, pages 663 - 676
OKITA, K.ICHISAKA, T.YAMANAKA, S., NATURE, vol. 450, 2007, pages 497 - 502
OKITA K ET AL., NAT. METHODS, vol. 8, no. 5, May 2011 (2011-05-01), pages 409 - 12
OKITA K ET AL., STEM CELLS., vol. 31, no. 3, pages 458 - 66
YU J.THOMSON JA. ET AL., SCIENCE, vol. 318, 2007, pages 1917 - 1920
SHI Y.DING S. ET AL., CELL STEM CELL, vol. 3, no. 5, 2008, pages 568 - 574
T. WAKAYAMA ET AL., SCIENCE, vol. 292, 2001, pages 740 - 743
S. WAKAYAMA ET AL., BIOL. REPROD., vol. 72, 2005, pages 932 - 936
J.B. CIBELLI ET AL., NATURE BIOTECHNOL., vol. 16, 1998, pages 642 - 646
SAYAKA WAKAYAMA ET AL., EXPERIMENTAL MEDICINE, vol. 26, no. 5, 2008, pages 47 - 52
LAFLAMME MAMURRY CE, NATURE, 2011
YANG L ET AL.: "Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population.", NATURE, vol. 453, no. 7194, 22 May 2008 (2008-05-22), pages 524 - 8, XP002561095, DOI: 10.1038/nature06894
LIAN X ET AL.: "Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling", PROC NATL ACAD SCI, vol. 109, no. 27, 3 July 2012 (2012-07-03), pages E1848 - 57, XP055053519, DOI: 10.1073/pnas.1200250109
MINAMI I ET AL.: "A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions", CELL REP., vol. 2, no. 5, 29 November 2012 (2012-11-29), pages 1448 - 60, XP055097336, DOI: 10.1016/j.celrep.2012.09.015
OKITA K ET AL., STEM CELLS, 29 November 2012 (2012-11-29)
OKITA ET AL., NAT METHODS, vol. 8, no. 5, 2011, pages 409 - 12
NAKAGAWA M ET AL., NAT BIOTECHNOL., vol. 26, 2008, pages 101 - 6
DUBOIS NC ET AL., NAT BIOTECHNOL., vol. 29, 2011, pages 1011 - 8
See also references of EP 3778587A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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