Title:
CARDIOMYOCYTE MATURATION PROMOTER
Document Type and Number:
WIPO Patent Application WO/2019/189554
Kind Code:
A1
Abstract:
The present invention provides a cardiomyocyte maturation promoter. The cardiomyocyte maturation promoter provided by the present invention comprises one or more compounds selected from among 2-methoxy-5-((Z)-2-(3,4,5-trimethoxyphenyl)vinyl)phenol, (1-ethyl-1H-benzotriazol-5-yl)methyl(2-(2-methoxy-4-methylphenyl)-4-methyl-1,3-thiazol-5-yl)carbamate, (2'beta)-22-oxovincaleukoblastine, 2-(2-(4-chlorophenyl)ethyl)-6-(2-furyl)-3H-imidazo[4,5-b]pyridine, 4,5-anhydro-1,2-dideoxy-4-methyl-2-((N-morpholin-4-ylacetyl)-L-alanyl-O-methyl-L-tyrosyl)amino)-1-phenyl-L-threo-pent-3-ulose, 3-(3-methoxyphenyl)-N7,N7-dimethylisoquinoline-1,7-diamine, methyl 4-(2-benzylbenzoyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate, 2'-(4-aminophenyl)-1H,1'H-2,5'-bibenzoimidazole-5-amine and salts thereof.
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Inventors:
YOSHIDA YOSHINORI (JP)
MIKI KENJI (JP)
KONDO SHIGERU (JP)
MIKI KENJI (JP)
KONDO SHIGERU (JP)
Application Number:
PCT/JP2019/013530
Publication Date:
October 03, 2019
Filing Date:
March 28, 2019
Export Citation:
Assignee:
UNIV KYOTO (JP)
TAKEDA PHARMACEUTICALS CO (JP)
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
C12N5/00; C12N5/077
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S. WAKAYAMA ET AL., BIOL. REPROD., vol. 72, 2005, pages 932 - 936
J.B. CIBELLI ET AL., NATURE BIOTECHNOL, vol. 16, 1998, pages 642 - 646
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MIKE CLEMENTS, ET AL.: "High-Throughput Multi-Parameter Profiling of Electrophysiological Drug Effects in Human Embryonic Stem Cell Derived Cardiomyocytes Using Multi-Electrode Arrays", TOXICOLOGICAL SCIENCES, ACADEMIC PRESS, vol. 140, no. 2, 1 August 2014 (2014-08-01), pages 445 - 461, XP055639318, ISSN: 1096-6080, DOI: 10.1093/toxsci/kfu084
ZENG, HAOYU ET AL.: "Use of FDSS/ /x Cell imaging platform for preclinical cardiac electrophysiology safety screening of compounds in human induced pluripotent stem cell -derived cardiomyocytes", JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, vol. 81, 2016, pages 217 - 222, XP029748128, DOI: 10.1016/j.vascn.2016.05.009
ZENG, HAOYU ET AL.: "Response of human induced pluripotent stem cell -derived cardiomyocytes to several pharmacological agents when intrinsic syncytial pacing is overcome by acute external stimulation", JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, vol. 91, 10 January 2018 (2018-01-10), pages 18 - 26, XP085378659, DOI: 10.1016/j.vascn.2017.12.004
RAST, GEORG ET AL.: "An integrated platform for simultaneous multi-well field potential recording and Fura-2-based calcium transitent ratiometry in human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes", JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, vol. 75, 2015, pages 91 - 100, XP029280135, DOI: 10.1016/j.vascn.2015.04.005
KANG JIESHENG, CHEN XIAO-LIANG, JI JUNZHI, LEI QIUBO, RAMPE DAVID: "Ca2+ channel activators reveal differential L-type Ca2+ channel pharmacology between native and stem cell -derived cardiomyocytes", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 341, no. 2, 2012, pages 510 - 517, XP009523831, DOI: 10.1124/jpet.112.192609
YAN P ET AL., BIOCHEM BIOPHYS RES COMMUN, vol. 379, 2009, pages 115 - 20
LAFLAMME MA ET AL., NAT BIOTECHNOL, vol. 25, 2007, pages 1015 - 1024
KIM JB.SCHOLER HR. ET AL., NATURE, vol. 454, 2008, pages 646 - 650
JOURNAL OF MEDICINAL CHEMISTRY, vol. 36, 1993, pages 2739 - 2744
M. J. EVANSM. H. KAUFMAN, NATURE, vol. 292, 1981, pages 154 - 156
J. A. THOMSON ET AL., SCIENCE, vol. 282, 1998, pages 1145 - 1147
J. A. THOMSON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 92, 1995, pages 7844 - 7848
J. A. THOMSON ET AL., BIOL. REPROD., vol. 55, 1996, pages 254 - 259
J. A. THOMSONV. S. MARSHALL, CURR. TOP. DEV. BIOL., vol. 38, 1998, pages 133 - 165
THOMSON JA ET AL., PROC NATL. ACAD. SCI. USA, vol. 92, 1995, pages 7844 - 7848
H. SUEMORI ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 345, 2006, pages 926 - 932
M. UENO ET AL., PROC. NATL. ACAD. SCI. USA, vol. 103, 2006, pages 9554 - 9559
H. SUEMORI ET AL., DEV. DYN., vol. 222, 2001, pages 273 - 279
H. KAWASAKI ET AL., PROC. NATL. ACAD. SCI. USA, vol. 99, 2002, pages 1580 - 1585
KLIMANSKAYA I ET AL., NATURE, vol. 444, 2006, pages 481 - 485
E. KROON ET AL., NAT. BIOTECHNOL., vol. 26, 2008, pages 443 - 452
M. KANATSU-SHINOHARA ET AL., BIOL. REPROD., vol. 69, 2003, pages 612 - 616
K. SHINOHARA ET AL., CELL, vol. 119, 2004, pages 1001 - 1012
HUANGFU D.MELTON, DA. ET AL., NATURE BIOTECHNOLOGY, vol. 26, no. 7, 2008, pages 795 - 797
Y. MATSUI ET AL., CELL, vol. 70, 1992, pages 841 - 847
J. L. RESNICK ET AL., NATURE, vol. 359, 1992, pages 550 - 551
TAKAHASHI KYAMANAKA S., CELL, vol. 126, 2006, pages 663 - 676
TAKAHASHI KYAMANAKA S. ET AL., CELL, vol. 131, 2007, pages 861 - 872
OKITA, K.ICHISAKA, T.YAMANAKA, S., NATURE, vol. 450, 2007, pages 497 - 502
OKITA K ET AL., NAT. METHODS, vol. 8, no. 5, May 2011 (2011-05-01), pages 409 - 12
OKITA K ET AL., STEM CELLS, vol. 31, no. 3, 29 November 2012 (2012-11-29), pages 458 - 66
YU J.THOMSON JA. ET AL., SCIENCE, vol. 318, 2007, pages 1917 - 1920
SHI Y.DING S. ET AL., CELL STEM CELL, vol. 3, 2008, pages 568 - 574
T. WAKAYAMA ET AL., SCIENCE, vol. 292, 2001, pages 740 - 743
S. WAKAYAMA ET AL., BIOL. REPROD., vol. 72, 2005, pages 932 - 936
J.B. CIBELLI ET AL., NATURE BIOTECHNOL, vol. 16, 1998, pages 642 - 646
SAYAKA WAKAYAMA ET AL., EXPERIMENTAL MEDICINE, vol. 26, no. 5, 2008, pages 47 - 52
"NCBI", Database accession no. NM 001164171
LAFLAMME MAMURRY CE, NATURE, 2011
YANG L ET AL.: "Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population", NATURE, vol. 453, no. 7194, 22 May 2008 (2008-05-22), pages 524 - 8, XP002561095, DOI: 10.1038/nature06894
LIAN X ET AL.: "Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling", PROC NATL ACAD SCI U S A, vol. 109, no. 27, 3 July 2012 (2012-07-03), pages E1848 - 57, XP055053519, DOI: 10.1073/pnas.1200250109
MINAMI I ET AL.: "A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions", CELL REP, vol. 2, no. 5, 29 November 2012 (2012-11-29), pages 1448 - 60, XP055097336, DOI: 10.1016/j.celrep.2012.09.015
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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