HETEROCYCLIC COMPOUNDS AS KRAS INHIBITORS, AND PREPARATION AND THERAPEUTIC USE THEREOF

Title:

HETEROCYCLIC COMPOUNDS AS KRAS INHIBITORS, AND PREPARATION AND THERAPEUTIC USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2024/046370

Kind Code:

A1

Abstract:

The present invention relates to compounds of formula (I) and formula (II), or pharmaceutically acceptable salts, prodrugs, tautomers, or stereoisomers and solvates thereof. Said compounds can be used for the treatment of cancers and inflammations of mammals. Also disclosed in the present invention are preparation methods for the compounds of formula (I) and formula (II), and pharmaceutical compositions comprising the compounds.

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Inventors:

TIAN HONGQI (CN)
HUANG GONGCHAO (CN)
GAO XUGUANG (CN)
LIU HUANHUAN (CN)

Application Number:

PCT/CN2023/115860

Publication Date:

March 07, 2024

Filing Date:

August 30, 2023

Export Citation:

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Assignee:

SHANGHAI KECHOW PHARMA INC (CN)

International Classes:

C07D519/00; A61K31/517; A61K31/519; A61P35/00

Domestic Patent References:

WO2023122662A1	2023-06-29
WO2023150284A2	2023-08-10
WO2022221739A1	2022-10-20
WO2022232331A1	2022-11-03
WO2021219072A1	2021-11-04

Foreign References:

CN113999226A	2022-02-01
TW202241869A	2022-11-01

Other References:

ZHANG ZIYANG, GUILEY KEELAN Z., SHOKAT KEVAN M.: "Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S)", NATURE CHEMICAL BIOLOGY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 18, no. 11, 1 November 2022 (2022-11-01), New York, pages 1177 - 1183, XP093032812, ISSN: 1552-4450, DOI: 10.1038/s41589-022-01065-9

Attorney, Agent or Firm:

WU, FENG & ZHANG (CN)

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