Title:
HIGH-PURITY COMPOUND PRODUCTION METHOD AND PURIFICATION METHOD
Document Type and Number:
WIPO Patent Application WO/2023/190663
Kind Code:
A1
Abstract:
The present invention provides an effective production method and/or purification method for a high-yield and high-purity (R)-11-[[-[(diethylamino)methyl]-1-piperidinyl]-acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepine-6-one or a salt thereof, said compound not containing impurities, particularly 11-(2-chloroacetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepine-6-one.
Inventors:
OHNO ATSUSHI (JP)
HONDA TAKAHIRO (JP)
HONDA TAKAHIRO (JP)
Application Number:
PCT/JP2023/012761
Publication Date:
October 05, 2023
Filing Date:
March 29, 2023
Export Citation:
Assignee:
SANTEN PHARMACEUTICAL CO LTD (JP)
International Classes:
C07D471/04; A61K31/5513; A61P27/02; A61P27/06
Domestic Patent References:
| WO2016078770A1 | 2016-05-26 | |||
| WO2022030489A1 | 2022-02-10 |
Foreign References:
| JPS60215683A | 1985-10-29 | |||
| JPH07504915A | 1995-06-01 | |||
| JPS6335573A | 1988-02-16 |
Other References:
ENGEL W W ET AL: "Tricyclic Compounds as Selective Muscarinic Receptor Antagonists. 3. Structure-Selectivity Relationships in a Series of Cardioselective (M2) Antimuscarinics", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 32, no. 8, 1 January 1989 (1989-01-01), US , pages 1718 - 1724, XP002166482, ISSN: 0022-2623, DOI: 10.1021/jm00128a008
MANDELLI GIACOMINA R., STEFANO MAIORANA, PATRIZIA TERNI, GIUSEPPINA LAMPERTI, MARIA LUISA COLIBRETTI, BRUNO P. IMBIMBO: "Synthesis of New Cardioselective M2 Muscarinic Receptor Antagonists ", CHEMICAL AND PHARMACEUTICAL BULLETIN, JP, vol. 48, no. 11, 1 November 2000 (2000-11-01), JP , pages 1611 - 1622, XP093095104, ISSN: 1347-5223, DOI: 10.1248/cpb.48.1611
WATANABE TOSHIHIRO, ISAO KINOYAMA, KENJI TAKIZAWA, SEIKO HIRANO, TADAO SHIBANUMA: "Synthesis and Biological Evaluation of 1, 2, 3, 4-Tetrahydroisoquinoline Derivatives as Potent and Selective M2 Muscarinic Receptor Antagonist", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 47, no. 5, 15 May 1999 (1999-05-15), JP , pages 672 - 677, XP093095127, ISSN: 0009-2363, DOI: 10.1248/cpb.47.672
WATANABE TOSHIHIRO, AKIO KAKEFUDA, ISAO KINOYAMA, KENJI TAKIZAWA, SEIKO HIRANO, HIROSHI SHIBATA, ISAO YANAGISAWA: "Synthesis of Novel Succinamide Derivatives Having a 5, 11-Dihydro-6H-pyrido[2, 3-b][1, 4]benzodiazepin-6-one Skeleton as Potent and Selective M2 Muscarinic Receptor Antagonists. II ", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 45, no. 9, 1 January 1997 (1997-01-01), JP , pages 1458 - 1469, XP093095132, ISSN: 0009-2363, DOI: 10.1248/cpb.45.1458
MANDELLI GIACOMINA R., STEFANO MAIORANA, PATRIZIA TERNI, GIUSEPPINA LAMPERTI, MARIA LUISA COLIBRETTI, BRUNO P. IMBIMBO: "Synthesis of New Cardioselective M2 Muscarinic Receptor Antagonists ", CHEMICAL AND PHARMACEUTICAL BULLETIN, JP, vol. 48, no. 11, 1 November 2000 (2000-11-01), JP , pages 1611 - 1622, XP093095104, ISSN: 1347-5223, DOI: 10.1248/cpb.48.1611
WATANABE TOSHIHIRO, ISAO KINOYAMA, KENJI TAKIZAWA, SEIKO HIRANO, TADAO SHIBANUMA: "Synthesis and Biological Evaluation of 1, 2, 3, 4-Tetrahydroisoquinoline Derivatives as Potent and Selective M2 Muscarinic Receptor Antagonist", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 47, no. 5, 15 May 1999 (1999-05-15), JP , pages 672 - 677, XP093095127, ISSN: 0009-2363, DOI: 10.1248/cpb.47.672
WATANABE TOSHIHIRO, AKIO KAKEFUDA, ISAO KINOYAMA, KENJI TAKIZAWA, SEIKO HIRANO, HIROSHI SHIBATA, ISAO YANAGISAWA: "Synthesis of Novel Succinamide Derivatives Having a 5, 11-Dihydro-6H-pyrido[2, 3-b][1, 4]benzodiazepin-6-one Skeleton as Potent and Selective M2 Muscarinic Receptor Antagonists. II ", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 45, no. 9, 1 January 1997 (1997-01-01), JP , pages 1458 - 1469, XP093095132, ISSN: 0009-2363, DOI: 10.1248/cpb.45.1458
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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