Title:
HIGH SENSITIVITY HYDROGEN SULFIDE RESPONSIVE NANOPROBE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/133961
Kind Code:
A1
Abstract:
A high sensitivity hydrogen sulfide responsive nanoprobe and a preparation method therefor. A preliminary attempt to the application of a nano fluorescent probe in the second near-infrared region is made. Compared with a common probe, the nano fluorescent probe in the second near-infrared region has deep tissue permeability capability and is hardly interfered by autofluorescence, and the EPR effect enables the probe to have longer retention time in tumor cells. Long-time high-temporal-spatial resolution living body second near-infrared region fluorescence and photoacoustic imaging can be realized, the photothermal therapy effect of tumors is remarkable, and integration of diagnosis and treatment of tumors is realized.
Inventors:
SHI HAIBIN (CN)
ZHANG YUQI (CN)
ZHANG YUQI (CN)
Application Number:
PCT/CN2022/076456
Publication Date:
July 20, 2023
Filing Date:
February 16, 2022
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
C09K11/02; A61K9/51; A61K41/00; A61K47/34; A61K49/00; A61K49/22; A61P35/00; B82Y5/00; B82Y20/00; B82Y40/00; C09K11/06; G01N21/64
Foreign References:
| CN111518545A | 2020-08-11 | |||
| CN110684017A | 2020-01-14 | |||
| CN106588906A | 2017-04-26 | |||
| CN106833607A | 2017-06-13 | |||
| CN108558738A | 2018-09-21 | |||
| CN109796444A | 2019-05-24 | |||
| US20120329085A1 | 2012-12-27 | |||
| US20160274123A1 | 2016-09-22 | |||
| US20190100654A1 | 2019-04-04 |
Other References:
PAN, JIAN ET AL.: "A Novel Fluorescent Probe for Rapid and Sensitive Detection of Hydrogen Sulfide in Living Cells", SPECTROCHIMICA ACTA PART A: MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, vol. 168, 2 June 2016 (2016-06-02), XP029623762, ISSN: 1386-1425, DOI: 10.1016/j.saa.2016.05.054
ZHANG YUQI, ZHAO MENG, FANG JING, YE SHUYUE, WANG ANNA, ZHAO YAN, CUI CHAOXIANG, HE LEI, SHI HAIBIN: "Smart On-Site Immobilizable Near-Infrared II Fluorescent Nanoprobes for Ultra-Long-Term Imaging-Guided Tumor Surgery and Photothermal Therapy", APPLIED MATERIALS & INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 13, no. 11, 24 March 2021 (2021-03-24), US , pages 12857 - 12865, XP093079501, ISSN: 1944-8244, DOI: 10.1021/acsami.0c22555
ZHANG YUQI, ZHAO MENG, FANG JING, YE SHUYUE, WANG ANNA, ZHAO YAN, CUI CHAOXIANG, HE LEI, SHI HAIBIN: "Smart On-Site Immobilizable Near-Infrared II Fluorescent Nanoprobes for Ultra-Long-Term Imaging-Guided Tumor Surgery and Photothermal Therapy", APPLIED MATERIALS & INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 13, no. 11, 24 March 2021 (2021-03-24), US , pages 12857 - 12865, XP093079501, ISSN: 1944-8244, DOI: 10.1021/acsami.0c22555
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT AND TRADEMARK AGENCY, LTD (CN)
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