Title:
HIGH STRENGTH AND TOUGHNESS PHOTOCROSSLINKED HYDROGEL MATERIAL, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/243835
Kind Code:
A1
Abstract:
The present invention relates to a high strength and toughness photocrosslinked hydrogel material, a preparation method therefor and the use thereof. The high strength and toughness photocrosslinked hydrogel material is prepared from an o-nitrobenzyl phototrigger-modified photosensitive polymer derivative, a double-bond functional group-modified polymer derivative, and a photoinitiator as raw materials. In the present invention, by controlling the average arm length of a polyethylene glycol and a derivative thereof in the o-nitrobenzyl phototrigger-modified photosensitive polymer derivative, and the molar ratio of an o-nitrobenzyl phototrigger to the polyethylene glycol and the derivative thereof, a significant improvement in hydrogel properties is thus achieved. Compared to hydrogel prepared by the prior art, the strength and/or toughness of the hydrogel prepared by the present invention are/is improved by one order of magnitude or more, the bottleneck problem of the poor mechanical properties of current hydrogels is solved, and the application range of the hydrogels is broadened.
Inventors:
SUN YU (CN)
Application Number:
PCT/CN2020/106113
Publication Date:
December 09, 2021
Filing Date:
July 31, 2020
Export Citation:
Assignee:
ZHONGSHAN GUANGHE MEDICAL TECH CO LTD (CN)
International Classes:
C08G65/333; C08J3/075; C08J3/24; C08L71/02
Foreign References:
| CN109776451A | 2019-05-21 | |||
| CN109880132A | 2019-06-14 | |||
| CN107987287A | 2018-05-04 | |||
| CN109776450A | 2019-05-21 | |||
| CN106822183A | 2017-06-13 | |||
| CN105131315A | 2015-12-09 |
Other References:
AZAGARSAMY MALAR A., MAROZAS IAN A., SPAANS SERGIO, ANSETH KRISTI S.: "Photoregulated Hydrazone-Based Hydrogel Formation for Biochemically Patterning 3D Cellular Microenvironments", ACS MACRO LETTERS, vol. 5, no. 1, 19 January 2016 (2016-01-19), pages 19 - 23, XP055878755, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.5b00682
DANIEL D. MCKINNON, TOBIN E. BROWN, KYLE A. KYBURZ, EMI KIYOTAKE, KRISTI S. ANSETH: "Design and Characterization of a Synthetically Accessible, Photodegradable Hydrogel for User-Directed Formation of Neural Networks", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 15, no. 7, 14 July 2014 (2014-07-14), US , pages 2808 - 2816, XP055667780, ISSN: 1525-7797, DOI: 10.1021/bm500731b
CREUSEN GUIDO, ROSHANASAN ARDESHIR, GARCIA LOPEZ JAVIER, PENEVA KALINA, WALTHER ANDREAS: "Bottom-up design of model network elastomers and hydrogels from precise star polymers", POLYMER CHEMISTRY, vol. 10, no. 27, 9 July 2019 (2019-07-09), pages 3740 - 3750, XP055878757, ISSN: 1759-9954, DOI: 10.1039/C9PY00731H
YANG JUN, GONG CHENG, SHI FU-KUAN, XIE XU-MING: "High Strength of Physical Hydrogels Based on Poly(acrylic acid)- g -poly(ethylene glycol) Methyl Ether: Role of Chain Architecture on Hydrogel Properties", JOURNAL OF PHYSICAL CHEMISTRY PART B, AMERICAN CHEMICAL SOCIETY, US, vol. 116, no. 39, 4 October 2012 (2012-10-04), US , pages 12038 - 12047, XP055878759, ISSN: 1520-6106, DOI: 10.1021/jp303710d
DANIEL D. MCKINNON, TOBIN E. BROWN, KYLE A. KYBURZ, EMI KIYOTAKE, KRISTI S. ANSETH: "Design and Characterization of a Synthetically Accessible, Photodegradable Hydrogel for User-Directed Formation of Neural Networks", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 15, no. 7, 14 July 2014 (2014-07-14), US , pages 2808 - 2816, XP055667780, ISSN: 1525-7797, DOI: 10.1021/bm500731b
CREUSEN GUIDO, ROSHANASAN ARDESHIR, GARCIA LOPEZ JAVIER, PENEVA KALINA, WALTHER ANDREAS: "Bottom-up design of model network elastomers and hydrogels from precise star polymers", POLYMER CHEMISTRY, vol. 10, no. 27, 9 July 2019 (2019-07-09), pages 3740 - 3750, XP055878757, ISSN: 1759-9954, DOI: 10.1039/C9PY00731H
YANG JUN, GONG CHENG, SHI FU-KUAN, XIE XU-MING: "High Strength of Physical Hydrogels Based on Poly(acrylic acid)- g -poly(ethylene glycol) Methyl Ether: Role of Chain Architecture on Hydrogel Properties", JOURNAL OF PHYSICAL CHEMISTRY PART B, AMERICAN CHEMICAL SOCIETY, US, vol. 116, no. 39, 4 October 2012 (2012-10-04), US , pages 12038 - 12047, XP055878759, ISSN: 1520-6106, DOI: 10.1021/jp303710d
Attorney, Agent or Firm:
SHANGHAI KESHENG INTELLECTUAL PROPERTY AGENCY LTD. (CN)
Download PDF: