Title:
HIGH THROUGH-PUT CLONING OF PROTOONCOGENES
Document Type and Number:
WIPO Patent Application WO2002057497
Kind Code:
A3
Abstract:
The present invention provides a process of identifying protooncogenes using high-throughput provirus tagging HPT, e.g., by recovering host/virus junction sequences from chimeric transcripts containing both host and virus sequences.
Inventors:
MORRIS DAVID W (US)
Application Number:
PCT/US2002/001651
Publication Date:
May 08, 2003
Filing Date:
January 18, 2002
Export Citation:
Assignee:
MORRIS DAVID W (US)
International Classes:
C12N15/90; C12N15/09; C12Q1/6886; C12Q1/70; C12Q1/68; C12Q1/686; (IPC1-7): C12Q1/68
Other References:
VAN LOHUIZEN M; VERBEEK S; SCHEIJEN B; WIENTJENS E; VAN DER GULDEN H; BERNS A.: "IDENTIFICATION OF COOPERATING ONCOGENES IN E-MU-MYC TRANSGENIC MICE BY provirus tagging", CELL, vol. 65, no. 5, 31 May 1991 (1991-05-31), NA US, pages 737, XP001109573
LI J ET AL: "Leukaemia disease genes: Large-scale cloning and pathway predictions", NATURE GENETICS, NATURE AMERICA, NEW YORK, US, vol. 23, no. 3, November 1999 (1999-11-01), pages 348 - 353, XP002223354, ISSN: 1061-4036
BERNS, A. ET AL.: "Identification and characterization of collaborating oncogenes in compound mutant mice", CANCER RESEARCH, vol. 59, no. 7 suppl., 1 April 1999 (1999-04-01), pages 1773S - 1777S, XP001109572
JACOBS H.: "TCR-independent T cell development mediated by gain-of-oncogene fucntion or loss-of-tumor-suppressor gene function", SEMIN IMMUNOL., vol. 12, no. 5, October 2000 (2000-10-01), pages 487 - 502, XP001148104
MIKKERS H. ET AL.: "High throughput retroviral tagging to identify components of specific signaling pathways in cancer", NAT GENET. 2002 SEP;32(1):, 19 August 2002 (2002-08-19) - September 2002 (2002-09-01), pages 153 - 159, XP001148101
LI J ET AL: "Leukaemia disease genes: Large-scale cloning and pathway predictions", NATURE GENETICS, NATURE AMERICA, NEW YORK, US, vol. 23, no. 3, November 1999 (1999-11-01), pages 348 - 353, XP002223354, ISSN: 1061-4036
BERNS, A. ET AL.: "Identification and characterization of collaborating oncogenes in compound mutant mice", CANCER RESEARCH, vol. 59, no. 7 suppl., 1 April 1999 (1999-04-01), pages 1773S - 1777S, XP001109572
JACOBS H.: "TCR-independent T cell development mediated by gain-of-oncogene fucntion or loss-of-tumor-suppressor gene function", SEMIN IMMUNOL., vol. 12, no. 5, October 2000 (2000-10-01), pages 487 - 502, XP001148104
MIKKERS H. ET AL.: "High throughput retroviral tagging to identify components of specific signaling pathways in cancer", NAT GENET. 2002 SEP;32(1):, 19 August 2002 (2002-08-19) - September 2002 (2002-09-01), pages 153 - 159, XP001148101
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