Title:
MDR1 VARIANTS AND METHODS FOR THEIR USE
Document Type and Number:
WIPO Patent Application WO2002057499
Kind Code:
A3
Abstract:
This invention provides the identification of a truncation polym orphism of the mdr1 gene that is linked to ivermectin sen sitivity in subjects, such as collies. Also provided are methods for detecting drug transport sensibility in a subject, and animal models and in vitro cell systems using cells from animals having an mdr1 truncation.
More Like This:
Inventors:
MEALEY KATRINA L (US)
BENTJEN STEVEN A (US)
BENTJEN STEVEN A (US)
Application Number:
PCT/US2002/000868
Publication Date:
November 27, 2003
Filing Date:
January 10, 2002
Export Citation:
Assignee:
UNIV WASHINGTON (US)
MEALEY KATRINA L (US)
BENTJEN STEVEN A (US)
MEALEY KATRINA L (US)
BENTJEN STEVEN A (US)
International Classes:
A61K49/00; C12N15/85; C12Q1/68; G01N33/68; (IPC1-7): C12Q1/68; G01N33/68; A01K67/027
Other References:
SCHINKEL ALFRED H ET AL: "N-glycosylation and deletion mutants of the human MDR1 P-glycoprotein.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 268, no. 10, 1993, pages 7474 - 7481, XP002241706, ISSN: 0021-9258
SCHINKEL A H ET AL: "Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs.", CELL, vol. 77, no. 4, 1994, pages 491 - 502, XP002077197, ISSN: 0092-8674
LANKAS GEORGE R ET AL: "P-Glycoprotein deficiency in a subpopulation of CF-1 mice enhances avermectin-induced neurotoxicity.", TOXICOLOGY AND APPLIED PHARMACOLOGY, vol. 143, no. 2, 1997, pages 357 - 365, XP002241707, ISSN: 0041-008X
RUETZ STEPHAN ET AL: "Functional expression of P-glycoprotein encoded by the mouse mdr3 gene in yeast cells.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 90, no. 24, 1993, 1993, pages 11588 - 11592, XP002241708, ISSN: 0027-8424
JUN KISUN ET AL: "Insertion of a retroviral solo long terminal repeat in mdr-3 locus disrupts mRNA splicing in mice.", MAMMALIAN GENOME, vol. 11, no. 10, October 2000 (2000-10-01), pages 843 - 848, XP002241709, ISSN: 0938-8990
MEALEY KATRINA L ET AL: "Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene.", PHARMACOGENETICS, vol. 11, no. 8, November 2001 (2001-11-01), pages 727 - 733, XP009010944, ISSN: 0960-314X
PIPPERT T R ET AL: "The subpopulation of CF-1 mice deficient in P-glycoprotein contains a murine retroviral insertion in the mdr1a gene.", JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY. UNITED STATES 2001, vol. 15, no. 2, 2001, pages 83 - 89, XP009010952, ISSN: 1095-6670
MEALEY KATRINA L ET AL: "Frequency of the mutant MDR1 allele associated with ivermectin sensitivity in a sample population of Collies from the northwestern United States.", AMERICAN JOURNAL OF VETERINARY RESEARCH, vol. 63, no. 4, April 2002 (2002-04-01), pages 479 - 481, XP009010943, ISSN: 0002-9645
ROULET ALAIN ET AL: "MDR1-deficient genotype in Collie dogs hypersensitive to the P-glycoprotein substrate ivermectin.", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 460, no. 2-3, 2003, pages 85 - 91, XP002241710, ISSN: 0014-2999
SCHINKEL A H ET AL: "P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.", THE JOURNAL OF CLINICAL INVESTIGATION. UNITED STATES 1 JUN 1996, vol. 97, no. 11, 1 June 1996 (1996-06-01), pages 2517 - 2524, XP002241711, ISSN: 0021-9738
SCHINKEL A H ET AL: "Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs.", CELL, vol. 77, no. 4, 1994, pages 491 - 502, XP002077197, ISSN: 0092-8674
LANKAS GEORGE R ET AL: "P-Glycoprotein deficiency in a subpopulation of CF-1 mice enhances avermectin-induced neurotoxicity.", TOXICOLOGY AND APPLIED PHARMACOLOGY, vol. 143, no. 2, 1997, pages 357 - 365, XP002241707, ISSN: 0041-008X
RUETZ STEPHAN ET AL: "Functional expression of P-glycoprotein encoded by the mouse mdr3 gene in yeast cells.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 90, no. 24, 1993, 1993, pages 11588 - 11592, XP002241708, ISSN: 0027-8424
JUN KISUN ET AL: "Insertion of a retroviral solo long terminal repeat in mdr-3 locus disrupts mRNA splicing in mice.", MAMMALIAN GENOME, vol. 11, no. 10, October 2000 (2000-10-01), pages 843 - 848, XP002241709, ISSN: 0938-8990
MEALEY KATRINA L ET AL: "Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene.", PHARMACOGENETICS, vol. 11, no. 8, November 2001 (2001-11-01), pages 727 - 733, XP009010944, ISSN: 0960-314X
PIPPERT T R ET AL: "The subpopulation of CF-1 mice deficient in P-glycoprotein contains a murine retroviral insertion in the mdr1a gene.", JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY. UNITED STATES 2001, vol. 15, no. 2, 2001, pages 83 - 89, XP009010952, ISSN: 1095-6670
MEALEY KATRINA L ET AL: "Frequency of the mutant MDR1 allele associated with ivermectin sensitivity in a sample population of Collies from the northwestern United States.", AMERICAN JOURNAL OF VETERINARY RESEARCH, vol. 63, no. 4, April 2002 (2002-04-01), pages 479 - 481, XP009010943, ISSN: 0002-9645
ROULET ALAIN ET AL: "MDR1-deficient genotype in Collie dogs hypersensitive to the P-glycoprotein substrate ivermectin.", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 460, no. 2-3, 2003, pages 85 - 91, XP002241710, ISSN: 0014-2999
SCHINKEL A H ET AL: "P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.", THE JOURNAL OF CLINICAL INVESTIGATION. UNITED STATES 1 JUN 1996, vol. 97, no. 11, 1 June 1996 (1996-06-01), pages 2517 - 2524, XP002241711, ISSN: 0021-9738
Download PDF:
Previous Patent: HIGH THROUGH-PUT CLONING OF PROTOONCOGENES
Next Patent: TREATMENT OF MOLTEN METAL WITH A PARTICULATE AGENT USING A MIXING IMPELLER
Next Patent: TREATMENT OF MOLTEN METAL WITH A PARTICULATE AGENT USING A MIXING IMPELLER