Title:
HIV PROTEASE INHIBITING COMPOUNDS
Document Type and Number:
WIPO Patent Application WO2005058841
Kind Code:
A3
Abstract:
A compound of the formula (I) is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
Inventors:
DEGOEY DAVID A (US)
FLENTGE CHARLES A (US)
FLOSI WILLIAM J (US)
GRAMPOVNIK DAVID J (US)
KEMPF DALE J (US)
KLEIN LARRY L (US)
YEUNG MING C (US)
RANDOLPH JOHN T (US)
WANG XIU C (US)
YU SU (US)
FLENTGE CHARLES A (US)
FLOSI WILLIAM J (US)
GRAMPOVNIK DAVID J (US)
KEMPF DALE J (US)
KLEIN LARRY L (US)
YEUNG MING C (US)
RANDOLPH JOHN T (US)
WANG XIU C (US)
YU SU (US)
Application Number:
PCT/US2004/041658
Publication Date:
March 09, 2006
Filing Date:
December 09, 2004
Export Citation:
Assignee:
ABBOTT LAB (US)
DEGOEY DAVID A (US)
FLENTGE CHARLES A (US)
FLOSI WILLIAM J (US)
GRAMPOVNIK DAVID J (US)
KEMPF DALE J (US)
KLEIN LARRY L (US)
YEUNG MING C (US)
RANDOLPH JOHN T (US)
WANG XIU C (US)
YU SU (US)
DEGOEY DAVID A (US)
FLENTGE CHARLES A (US)
FLOSI WILLIAM J (US)
GRAMPOVNIK DAVID J (US)
KEMPF DALE J (US)
KLEIN LARRY L (US)
YEUNG MING C (US)
RANDOLPH JOHN T (US)
WANG XIU C (US)
YU SU (US)
International Classes:
C07D213/30; C07D213/40; C07D401/06; C07D401/12; C07D401/14; C07D417/06; C07D417/14; C07D471/04; C07D493/04; (IPC1-7): C07D401/06; C07D213/40; C07D417/14; C07D401/14; C07D401/12; C07D417/06; C07D471/04; C07D213/30; C07D493/04; A61K31/427; A61K31/4439; A61K31/4436; A61P31/18
Foreign References:
| US5294720A | 1994-03-15 | |||
| US5142056A | 1992-08-25 |
Other References:
NILLROTH ULRIKA ET AL: "Human immunodeficiency virus type 1 proteinase resistance to symmetric cyclic urea inhibitor analogs", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 41, no. 11, November 1997 (1997-11-01), pages 2383 - 2388, XP002341730, ISSN: 0066-4804
KEMPF D J ET AL: "ANTIVIRAL AND PHARMACOKINETIC PROPERTIES OF C2 SYMMETRIC INHIBITORSOF THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 35, no. 11, November 1991 (1991-11-01), pages 2209 - 2214, XP000983237, ISSN: 0066-4804
TOSSI ALESSANDRO ET AL: "Aspartic protease inhibitors: An integrated approach for the design and synthesis of diaminodiol-based peptidomimetics", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 267, no. 6, March 2000 (2000-03-01), pages 1715 - 1722, XP002341731, ISSN: 0014-2956
ETTMAYER PETER ET AL: "Novel, extended transition state mimic in HIV-1 protease inhibitors with peripheral C-2-symmetry", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 4, no. 24, 1994, pages 2851 - 2856, XP002341732, ISSN: 0960-894X
KEMPF D J ET AL: "ANTIVIRAL AND PHARMACOKINETIC PROPERTIES OF C2 SYMMETRIC INHIBITORSOF THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 35, no. 11, November 1991 (1991-11-01), pages 2209 - 2214, XP000983237, ISSN: 0066-4804
TOSSI ALESSANDRO ET AL: "Aspartic protease inhibitors: An integrated approach for the design and synthesis of diaminodiol-based peptidomimetics", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 267, no. 6, March 2000 (2000-03-01), pages 1715 - 1722, XP002341731, ISSN: 0014-2956
ETTMAYER PETER ET AL: "Novel, extended transition state mimic in HIV-1 protease inhibitors with peripheral C-2-symmetry", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 4, no. 24, 1994, pages 2851 - 2856, XP002341732, ISSN: 0960-894X
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