SUBSTITUTED 6-CYCLOHEXYLALKYL SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE) POLYMERASE INHIBITORS

Title:

SUBSTITUTED 6-CYCLOHEXYLALKYL SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE) POLYMERASE INHIBITORS

Document Type and Number:

WIPO Patent Application WO2005058843

Kind Code:

A8

Abstract:

The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, s, R¹, R², R³, Q, X and Y have defined meanings.

Inventors:

MABIRE DOMINIQUE JEAN-PIERRE (FR)
VAN DUN JACOBUS ALPHONSUS JOSE (BE)
SOMERS MARIA VICTORINA FRANCIS (BE)
WOUTERS WALTER BOUDEWIJN LEOPO (BE)

Application Number:

PCT/EP2004/013165

Publication Date:

June 15, 2006

Filing Date:

November 18, 2004

Export Citation:

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Assignee:

JANSSEN PHARMACEUTICA NV (BE)
MABIRE DOMINIQUE JEAN-PIERRE (FR)
VAN DUN JACOBUS ALPHONSUS JOSE (BE)
SOMERS MARIA VICTORINA FRANCIS (BE)
WOUTERS WALTER BOUDEWIJN LEOPO (BE)

International Classes:

C07D241/44; C07D215/227; C07D401/06; C07D401/14; C07D409/14; C07D491/10; C07D215/22

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