Title:
HUMAN GALECTIN-4-LIKE PROTEIN AND cDNA ENCODING THE SAME
Document Type and Number:
WIPO Patent Application WO/1997/003190
Kind Code:
A1
Abstract:
A galectin-4 (a lactose-binding protein)-like protein expressed specifically in the stomach and intestines and a human cDNA encoding the same. The protein is one containing the amino acid sequence represented by SEQ ID NO: 1 while the gene is a cDNA containing the base sequence represented by SEQ ID NO: 2. The protein which is the expression product of this cDNA has a lactose-binding activity and is applicable to drugs and research reagents.
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Inventors:
KATO SEISHI (JP)
YAMAGUCHI TOMOKO (JP)
SEKINE SHINGO (JP)
KAMATA KOUJU (JP)
YAMAGUCHI TOMOKO (JP)
SEKINE SHINGO (JP)
KAMATA KOUJU (JP)
Application Number:
PCT/JP1996/001899
Publication Date:
January 30, 1997
Filing Date:
July 09, 1996
Export Citation:
Assignee:
SAGAMI CHEM RES (JP)
KATO SEISHI (JP)
YAMAGUCHI TOMOKO (JP)
SEKINE SHINGO (JP)
KAMATA KOUJU (JP)
KATO SEISHI (JP)
YAMAGUCHI TOMOKO (JP)
SEKINE SHINGO (JP)
KAMATA KOUJU (JP)
International Classes:
C07K14/47; C12N15/12; A61K38/00; (IPC1-7): C12N15/12; C12N15/62; C12N15/63; C12P21/02
Other References:
J. BIOL. CHEM., (1993), Vol. 268, No. 8, YUKO ODA et al., "Soluble Lactose-binding Lectin from Rat Intestine with Two Different Carbohydrate-binding Domains in the Same Peptide Chain", p. 5929-5939
JOURNAL OF CELLULAR BIOCHEMISTRY SUPPLEMENT, (Apr. 1995), Vol. 57, No. 19B, HUFLEJT M.E. et al., "Galectin-4 Expression in Human Adenocarcinomas is Correlated with a Highly Differentiated Phenotype", p. 20.
JOURNAL OF INVESTIGATIVE DERMATOLOGY, (May 1995), Vol. 104, No. 4, HU P. et al., "Isolation of Human cDNA for Galectin-4 the Homolog of a Pig Lactose-Binding Adherens Injunction Protein", p. 644.
FEBS LETTERS, (13 Feb. 1995), Vol. 359, TARDY F. et al., "Purification and Characterization of the N-terminal Domain of Galectin-4 from Rat Small Intestine", p. 169-172.
CELL, (1994), Vol. 76, No. 4, FEIZI T. et al., "Galectins: A Family of Animal beta-Glactoside-Binding Lectins", p. 597-598.
See also references of EP 0841393A4
JOURNAL OF CELLULAR BIOCHEMISTRY SUPPLEMENT, (Apr. 1995), Vol. 57, No. 19B, HUFLEJT M.E. et al., "Galectin-4 Expression in Human Adenocarcinomas is Correlated with a Highly Differentiated Phenotype", p. 20.
JOURNAL OF INVESTIGATIVE DERMATOLOGY, (May 1995), Vol. 104, No. 4, HU P. et al., "Isolation of Human cDNA for Galectin-4 the Homolog of a Pig Lactose-Binding Adherens Injunction Protein", p. 644.
FEBS LETTERS, (13 Feb. 1995), Vol. 359, TARDY F. et al., "Purification and Characterization of the N-terminal Domain of Galectin-4 from Rat Small Intestine", p. 169-172.
CELL, (1994), Vol. 76, No. 4, FEIZI T. et al., "Galectins: A Family of Animal beta-Glactoside-Binding Lectins", p. 597-598.
See also references of EP 0841393A4
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