Title:
HUMANIZED ANTI-TPBG ANTIBODY, PREPARATION METHOD THEREFOR, CONJUGATE THEREOF, AND APPLICATIONS
Document Type and Number:
WIPO Patent Application WO/2018/184558
Kind Code:
A1
Abstract:
The present invention provides a humanized anti-TPBG antibody, a preparation method therefor, a conjugate thereof, and applications. The humanized anti-TPBG antibody comprises: (a), a framework region comprising a residue of a human antibody framework region; and (b) one or more CDRs of a light-chain variable region as shown in the SEQ ID NO.4 or 8 or one or more CDRs of a heavy-chain variable region as shown in the SEQ ID NO.2 or 6.
Inventors:
ZHANG YING (CN)
GONG SHIYONG (CN)
SUN XIAOLAN (CN)
XU TENGJIAO (CN)
PENG FEI (CN)
CHEN YUZHU (CN)
LIU LILE (CN)
GONG SHIYONG (CN)
SUN XIAOLAN (CN)
XU TENGJIAO (CN)
PENG FEI (CN)
CHEN YUZHU (CN)
LIU LILE (CN)
Application Number:
PCT/CN2018/081853
Publication Date:
October 11, 2018
Filing Date:
April 04, 2018
Export Citation:
Assignee:
XDCEXPLORER SHANGHAI CO LTD (CN)
International Classes:
C07K16/00; A61K39/395; A61P35/00; C12N15/00
Foreign References:
| CN106916227A | 2017-07-04 | |||
| CN101437850A | 2009-05-20 | |||
| CN101035564A | 2007-09-12 | |||
| CN201710218524A | 2017-04-05 | |||
| US5208020A | 1993-05-04 |
Other References:
DAMELIN M. ET AL.: "Evolving Strategies for Target Selection for Antibody-Drug Conjugates", PHARMACEUTICAL RESEARCH, vol. 32, no. 11, October 2015 (2015-10-01), pages 3494 - 3507, XP035553871
CASTRO, F.V. ET AL.: "Regulation of autologous immunity to the mouse 5T4 oncofoetal antigen: implications for immunotherapy", CANCER IMMUNOLOGY, IMMUNOTHERAPY, vol. 61, no. 7, 30 November 2011 (2011-11-30), pages 1005 - 1018, XP035074375
KOHLERMILSTEIN, NATURE, vol. 25, 1975, pages 495
MARTIN ET AL., METHODS ENZYMOL., vol. 203, 1991, pages 121 - 153
MARTIN ET AL., PROC. NAT 1. ACAD. SCI. USA, vol. 86, 1989, pages 9268 - 9272
PEDERSEN ET AL., LMMUNOMETHODS, vol. 1, 1992, pages 126
PADLAN ET AL., FASEB J., vol. 9, 1995, pages 133 - 139
PADLAN, MOL. IMMUNOL., vol. 28, 1991, pages 489 - 980
POTTER ET AL., INT. REV. IMMUNOL., vol. 10, no. 2-3, 1993, pages 103 - 112
HOUDEBINE, CURR. OPIN. BIOTECHNO J., vol. 13, no. 6, 2002, pages 625 - 629
SCHILLBERG ET AL., CELL MOL. LIFE SCI., vol. 60, no. 3, 2003, pages 433 - 45
CHEN DSMELLMAN I, ONCOLOGY MEETS IMMUNOLOGY: THE CANCER-IMMUNITY CYCLE [J]. IMMUNITY, vol. 39, no. 1, 2013, pages 1 - 10
BERKOW ET AL.: "The Merck Manual of Medical Information and Merck&Co.Inc.", 2000, WHITEHOUSE STATION
EBADI, CRC DESK REFERENCE OF CLINICAL PHARMACOLOGY AND ETC, 1998
"Genbank", Database accession no. CAA09931.1
SAMBROOK, J.FRITSCH, E. F.MANIATIS, T.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
METHODS IN ENZYMOLOGY, vol. 220
KABAT: "Sequences of Proteins of Immunological Interest", 1991, NATIONAL INSTITUTES OF HEALTH
DORONINA, BIOCONJUGATE CHEM., vol. 17, 2006, pages 114 - 124
See also references of EP 3608335A4
CASTRO, F.V. ET AL.: "Regulation of autologous immunity to the mouse 5T4 oncofoetal antigen: implications for immunotherapy", CANCER IMMUNOLOGY, IMMUNOTHERAPY, vol. 61, no. 7, 30 November 2011 (2011-11-30), pages 1005 - 1018, XP035074375
KOHLERMILSTEIN, NATURE, vol. 25, 1975, pages 495
MARTIN ET AL., METHODS ENZYMOL., vol. 203, 1991, pages 121 - 153
MARTIN ET AL., PROC. NAT 1. ACAD. SCI. USA, vol. 86, 1989, pages 9268 - 9272
PEDERSEN ET AL., LMMUNOMETHODS, vol. 1, 1992, pages 126
PADLAN ET AL., FASEB J., vol. 9, 1995, pages 133 - 139
PADLAN, MOL. IMMUNOL., vol. 28, 1991, pages 489 - 980
POTTER ET AL., INT. REV. IMMUNOL., vol. 10, no. 2-3, 1993, pages 103 - 112
HOUDEBINE, CURR. OPIN. BIOTECHNO J., vol. 13, no. 6, 2002, pages 625 - 629
SCHILLBERG ET AL., CELL MOL. LIFE SCI., vol. 60, no. 3, 2003, pages 433 - 45
CHEN DSMELLMAN I, ONCOLOGY MEETS IMMUNOLOGY: THE CANCER-IMMUNITY CYCLE [J]. IMMUNITY, vol. 39, no. 1, 2013, pages 1 - 10
BERKOW ET AL.: "The Merck Manual of Medical Information and Merck&Co.Inc.", 2000, WHITEHOUSE STATION
EBADI, CRC DESK REFERENCE OF CLINICAL PHARMACOLOGY AND ETC, 1998
"Genbank", Database accession no. CAA09931.1
SAMBROOK, J.FRITSCH, E. F.MANIATIS, T.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
METHODS IN ENZYMOLOGY, vol. 220
KABAT: "Sequences of Proteins of Immunological Interest", 1991, NATIONAL INSTITUTES OF HEALTH
DORONINA, BIOCONJUGATE CHEM., vol. 17, 2006, pages 114 - 124
See also references of EP 3608335A4
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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