Title:
HYBRID PROTEIN FOR INHIBITING THE DEGRANULATION OF MASTOCYTES AND THE USE THEREOF
Document Type and Number:
WIPO Patent Application WO1999058571
Kind Code:
A3
Abstract:
The invention relates to a hybrid protein comprising or comprised of (i) a known protein which binds to mastocytes and/or basophils in a known manner and/or is absorbed thereby, and of (ii) a protease which splits one or more proteins of the secretory apparatus of the mastocytes and/or basophils.
Inventors:
BIGALKE HANS (DE)
FREVERT JUERGEN (DE)
FREVERT JUERGEN (DE)
Application Number:
PCT/EP1999/003272
Publication Date:
February 03, 2000
Filing Date:
May 12, 1999
Export Citation:
Assignee:
BIOTECON GES FUER BIOTECHNOLOGISCHE ENTWICKLUNG & CONSULTING MBH (DE)
BIGALKE HANS (DE)
FREVERT JUERGEN (DE)
BIGALKE HANS (DE)
FREVERT JUERGEN (DE)
International Classes:
A61K31/445; A61K38/00; C12N9/50; A61K39/395; A61K47/48; A61P37/08; A61P43/00; C07K14/47; C07K16/00; C07K16/28; C07K19/00; (IPC1-7): C07K19/00; A61K38/16
Domestic Patent References:
| WO1997022364A1 | 1997-06-26 |
Other References:
LUSTGARTEN, JOSEPH ET AL: "Prolonged inhibition of IgE production in mice following treatment with a IgE-specific immunotoxin", MOL. IMMUNOL. (1996), 33(3), 245-251, XP002124080
SLATER, JAY E. ET AL: "IgE immunotoxins. Effect of an IgE -ricin A chain conjugate on rat skin histamine content", J. IMMUNOL. (1988), 140(3), 807-11, XP002124081
SLATER, JAY E. ET AL: "IgE immunotoxins. Effect of an IgE -ricin A chain conjugate on rat skin histamine content", J. IMMUNOL. (1988), 140(3), 807-11, XP002124081
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