HYBRID TYPE COMPOUND OR SALT THEREOF

Title:

HYBRID TYPE COMPOUND OR SALT THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/238919

Kind Code:

A1

Abstract:

Provided is an anticancer agent capable of efficaciously acting on a Ras mutated cancer.　The present invention provides a hybrid type compound, in which trametinib is linked to an Akt inhibitor via a linker, or a salt thereof.

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Inventors:

WATANABE YOSHIHIRO (JP)
KUNISHIMA MUNETAKA (JP)
FUJITA HIKARU (JP)
YANO SEIJI (JP)
ARAI SACHIKO (JP)
TAMAI IKUMI (JP)
ARAKAWA HIROSHI (JP)
INOKUMA YASUHIDE (JP)

Application Number:

PCT/JP2023/021442

Publication Date:

December 14, 2023

Filing Date:

June 09, 2023

Export Citation:

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Assignee:

WATANABE YOSHIHIRO (JP)

International Classes:

A61K47/55; A61K31/519; A61P35/00; C07D471/04; C07D519/00

Foreign References:

JP2019519593A

2019-07-11

Other References:

YOSHIDA TAKAYUKI, KAKEGAWA JUNYA, YAMAGUCHI TAKAYUKI, HANTANI YOSHIJI, OKAJIMA NOBUYUKI, SAKAI TOSHIYUKI, WATANABE YOSHIHIRO, NAKA: "Identification and Characterization of a Novel Chemotype MEK Inhibitor Able to Alter the Phosphorylation State of MEK1/2", ONCOTARGET, IMPACT JOURNALS LLC, UNITED STATES, vol. 3, no. 12, 31 December 2012 (2012-12-31), United States , pages 1533 - 1545, XP093114742, ISSN: 1949-2553, DOI: 10.18632/oncotarget.747
WU Y. LINDA, MAACHANI UDAY BHANU, SCHWEITZER MELANIE, SINGH RANJODH, WANG MELINDA, CHANG RAYMOND, SOUWEIDANE MARK M.: "Dual Inhibition of PI3K/AKT and MEK/ERK Pathways Induces Synergistic Antitumor Effects in Diffuse Intrinsic Pontine Glioma Cells", TRANSLATIONAL ONCOLOGY, NEOPLASIA PRESS, UNITED STATES, vol. 10, no. 2, 1 April 2017 (2017-04-01), United States , pages 221 - 228, XP093114743, ISSN: 1936-5233, DOI: 10.1016/j.tranon.2016.12.008

Attorney, Agent or Firm:

HIRAKI & ASSOCIATES (JP)

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