Title:
HYDROXYL COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES
Document Type and Number:
WIPO Patent Application WO2004067489
Kind Code:
A8
Abstract:
The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
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Inventors:
DASSEUX JEAN-LOUIS HENRI (US)
ONICIU DANIELA CARMEN (US)
ONICIU DANIELA CARMEN (US)
Application Number:
PCT/US2003/041411
Publication Date:
February 17, 2005
Filing Date:
December 23, 2003
Export Citation:
Assignee:
ESPERION THERAPEUTICS INC (US)
DASSEUX JEAN-LOUIS HENRI (US)
ONICIU DANIELA CARMEN (US)
DASSEUX JEAN-LOUIS HENRI (US)
ONICIU DANIELA CARMEN (US)
International Classes:
A61P3/10; C07C31/20; C07C31/22; C07C31/24; C07C59/11; C07C59/245; C07C59/285; C07C59/29; C07C59/46; C07C59/48; C07C59/54; C07C62/02; C07C62/06; C07C65/17; C07C69/757; C07D213/80; C07D309/10; C07D309/12; C07D405/12; C07F9/09; C07F9/117; C07F9/24; C07F9/44; (IPC1-7): C07C31/22; C07C31/20; C07C59/105; C07C59/245; C07C261/04; C07C311/24; C07F9/06; C07F9/22; C07D257/04; C07D207/44; C07D261/12; C07D233/02; C07D309/38; A61P3/10; A61K31/047
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