Title:
INTERFERON ALPHA 2a MODIFIED BY POLYETHYLENE GLYCOL, ITS SYNTHESIS PROCESS AND APPLICATION
Document Type and Number:
WIPO Patent Application WO/2009/030065
Kind Code:
A1
Abstract:
Interferon alpha 2a modified by polyethylene glycol with Y-type branch in the particular lysine site, synthesis process thereof and the application of the resulting single site pegylated interferon alpha 2a in the preparation of drugs.
Inventors:
ZHOU WEIDONG (CN)
XIAO QINGJIANG (CN)
SUN LI (CN)
WANG TIEBING (CN)
LIU BIN (CN)
LIN SONG (CN)
LIU MIN (CN)
YIN FENGHONG (CN)
ZHUANG LU (CN)
LEI LIFANG (CN)
XIAO QINGJIANG (CN)
SUN LI (CN)
WANG TIEBING (CN)
LIU BIN (CN)
LIN SONG (CN)
LIU MIN (CN)
YIN FENGHONG (CN)
ZHUANG LU (CN)
LEI LIFANG (CN)
Application Number:
PCT/CN2007/002643
Publication Date:
March 12, 2009
Filing Date:
September 04, 2007
Export Citation:
Assignee:
BIOSTEED GENE EXPRESSION TECH (CN)
ZHOU WEIDONG (CN)
XIAO QINGJIANG (CN)
SUN LI (CN)
WANG TIEBING (CN)
LIU BIN (CN)
LIN SONG (CN)
LIU MIN (CN)
YIN FENGHONG (CN)
ZHUANG LU (CN)
LEI LIFANG (CN)
ZHOU WEIDONG (CN)
XIAO QINGJIANG (CN)
SUN LI (CN)
WANG TIEBING (CN)
LIU BIN (CN)
LIN SONG (CN)
LIU MIN (CN)
YIN FENGHONG (CN)
ZHUANG LU (CN)
LEI LIFANG (CN)
International Classes:
C07K14/56; A61K38/21; A61K47/48; A61P1/16; A61P11/00; A61P11/06; A61P19/02; A61P25/00; A61P31/12; A61P35/00; C07K17/08
Foreign References:
| CN1243779C | 2006-03-01 | |||
| CN1711109A | 2005-12-21 | |||
| US4179337A | 1979-12-18 | |||
| EP0593868A1 | 1994-04-27 | |||
| EP0809996A2 | 1997-12-03 | |||
| CN1243779C | 2006-03-01 |
Other References:
KENJI ORITANI; PAUL W KINCADE ET AL.: "Type I interferon and limitin: a comparison of structures, receptors, and functions", CYTOKINE AND GROWTH FACTOR REVIEWS, vol. 12, 2001, pages 337 - 348
YU-SEN WANG; STEPHEN YOUNGSTER ET AL.: "Structural and biological characterization of PEGylated recombinant interferon alpha-2b and its therapeutic implications", ADVANCE DRUG DELIVERY REVIEWS, vol. 54, 2002, pages 547 - 570
HENCO K.; BROSIUS F.J. ET AL., J. MOL. BIOL., vol. 185, 1985, pages 227 - 260
INADA ET AL., J. BIOACT. AND COMPATIBLE POLYMERS, vol. 5, 1990, pages 343
DELGADO ET AL., CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, vol. 9, 1992, pages 249
KATRE, ADVANCED DRUG DELIVERY SYSTEMS, vol. 10, 1993, pages 91
SATAKE-ISHIKAWA ET AL., CELL STRUCTURE AND FUNCTION, vol. 17, 1992, pages 157 - 160
KATRE ET AL., PROC. NATL. ACAD. SCI. USA, vol. 84, 1987, pages 1487
TSUTSUMI ET AL., JPN. J. CANCER RES., vol. 85, 1994, pages 9
INOUE ET AL., J. LAB. CLIN. MED., vol. 124, 1994, pages 529
CHAMOW ET AL., BIOCONJ. CHEM., vol. 5, 1994, pages 133
MONFARDINI ET AL., BIOCONJUGATE CHEM., vol. 6, 1995, pages 62
YU-SEN WANG ET AL., ADVANCED DRUG DELIVERY REVIEWS, vol. 54, 2002, pages 547 - 570
YU-SEN WANG ET AL., BIOCHEMISTRY, vol. 39, 2000, pages 10634 - 10640
LAEMMLI ET AL., NATURE, vol. 227, 1970, pages 680
PHARMACOPOEIA OF THE PEOPLE'S REPUBLIC OF CHINA, vol. 3, 2005
YU-SEN WANG; STEPHEN YOUNGSTER ET AL.: "Structural and biological characterization of PEGylated recombinant interferon alpha-2b and its therapeutic implications", ADVANCE DRUG DELIVERY REVIEWS, vol. 54, 2002, pages 547 - 570
HENCO K.; BROSIUS F.J. ET AL., J. MOL. BIOL., vol. 185, 1985, pages 227 - 260
INADA ET AL., J. BIOACT. AND COMPATIBLE POLYMERS, vol. 5, 1990, pages 343
DELGADO ET AL., CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, vol. 9, 1992, pages 249
KATRE, ADVANCED DRUG DELIVERY SYSTEMS, vol. 10, 1993, pages 91
SATAKE-ISHIKAWA ET AL., CELL STRUCTURE AND FUNCTION, vol. 17, 1992, pages 157 - 160
KATRE ET AL., PROC. NATL. ACAD. SCI. USA, vol. 84, 1987, pages 1487
TSUTSUMI ET AL., JPN. J. CANCER RES., vol. 85, 1994, pages 9
INOUE ET AL., J. LAB. CLIN. MED., vol. 124, 1994, pages 529
CHAMOW ET AL., BIOCONJ. CHEM., vol. 5, 1994, pages 133
MONFARDINI ET AL., BIOCONJUGATE CHEM., vol. 6, 1995, pages 62
YU-SEN WANG ET AL., ADVANCED DRUG DELIVERY REVIEWS, vol. 54, 2002, pages 547 - 570
YU-SEN WANG ET AL., BIOCHEMISTRY, vol. 39, 2000, pages 10634 - 10640
LAEMMLI ET AL., NATURE, vol. 227, 1970, pages 680
PHARMACOPOEIA OF THE PEOPLE'S REPUBLIC OF CHINA, vol. 3, 2005
Attorney, Agent or Firm:
NTD PATENT & TRADEMARK AGENCY LIMITED BEIJING OFFICE (Block A Investment Plaza, 27 Jinrongdajie, Beijing 2, CN)
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