Title:
IBUPROFEN ESTER DERIVATIVE AND EMULSION FORMULATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/272472
Kind Code:
A1
Abstract:
The present application relates to an ibuprofen ester derivative and an emulsion formulation thereof. In the present application, a carboxyl group of racemic ibuprofen or S-ibuprofen is derivatized to obtain a compound N9 and a dextrorotatory enantiomer thereof N9(S), and an emulsion formulation is prepared therefrom. The present invention overcomes certain safety and patient compliance problems in clinical applications of existing ibuprofen/dexibuprofen injections, and achieves the purposes of reducing vascular irritation, increasing clinical use methods, and improving the stability of preparations in clinical applications.
Inventors:
YE HAI (CN)
ZHOU WENLIANG (CN)
WANG JIALIN (CN)
XU YING (CN)
MIN TAO (CN)
LV TIAN (CN)
CHEN XINGRAN (CN)
ZHOU WENLIANG (CN)
WANG JIALIN (CN)
XU YING (CN)
MIN TAO (CN)
LV TIAN (CN)
CHEN XINGRAN (CN)
Application Number:
PCT/CN2021/102989
Publication Date:
January 05, 2023
Filing Date:
June 29, 2021
Export Citation:
Assignee:
NANJING HERON PHARMACEUTICAL SCIENCE AND TECH CO LTD (CN)
International Classes:
C07C69/96; A61K9/107; A61K31/222; A61P29/00; C07C68/00
Domestic Patent References:
| WO2020101543A1 | 2020-05-22 |
Foreign References:
| US4851426A | 1989-07-25 | |||
| CN103003228A | 2013-03-27 | |||
| CN102336714A | 2012-02-01 | |||
| CN105017157A | 2015-11-04 | |||
| CN101253148A | 2008-08-27 |
Other References:
BEN-SHABA SHIMON, DOMB ABRAHAM J.: "Synthesis of Pendent Carbonate Ester Groups onto Aliphatic Polycarbonates", JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, SAGE, US, vol. 21, no. 5, 1 September 2006 (2006-09-01), US , pages 385 - 397, XP055900991, ISSN: 0883-9115, DOI: 10.1177/0883911506068563
"Chinese Pharmacopoeia", 2020
See also references of EP 4134362A4
"Chinese Pharmacopoeia", 2020
See also references of EP 4134362A4
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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