Title:
ICOTINIB-CONTAINING TOPICAL SKIN PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/051763
Kind Code:
A1
Abstract:
Disclosed are a topical preparation for inhibiting tyrosine kinase and a preparation method thereof, and especially a topical pharmaceutical composition for inhibiting tyrosine kinase and a preparation method thereof. The active ingredient of the topical preparation is Icotinib or a pharmaceutically acceptable salt thereof. This formulation is suitable for topical application, and has the advantage little skin irritation, and no adverse reactions such as pruritus, burning sensations, tingling, dry skin, redness and rashes, and long-term use does not produce parahormone-related side effects such as skin atrophy, pigmentation or degeneration, as well as having no related dermatological symptoms after drug withdrawal. The preparation method has the advantages of beingsimple, easy to operate and control, easily industrialized and so on.
Inventors:
WANG YINXIANG (CN)
YUAN SHUJUN (CN)
WANG YANPING (CN)
HU SHAOJING (CN)
HU YUNYAN (CN)
YUAN SHUJUN (CN)
WANG YANPING (CN)
HU SHAOJING (CN)
HU YUNYAN (CN)
Application Number:
PCT/CN2014/088344
Publication Date:
April 16, 2015
Filing Date:
October 11, 2014
Export Citation:
Assignee:
BETTA PHARMACEUTICALS CO LTD (CN)
International Classes:
A61K31/519; A61K9/06; A61P17/00; A61P35/00
Domestic Patent References:
| WO2010003313A1 | 2010-01-14 | |||
| WO2010003313A1 | 2010-01-14 |
Other References:
XIE, XIAODONG ET AL.: "Research Status and the Latest Development of EGFR-TKI Related Skin Toxic Reaction", PROCEEDINGS OF THE 8TH ACADEMIC CONFERENCE OF THE CHINESE COMMITTEE OF REHABILITATION AND PALLIATIVE CARE, 14 October 2012 (2012-10-14), pages 160 - 165, XP008183458
ZHAO, QIONG ET AL.: "Spared Pre-irradiated Area in Pustular Lesions Induced by Icotinib Showing Decreased Expressions of CD 1a+ Langerhans Cells and FGFR2.", JAPANESE JOURNAL OF CLINICAL ONCOLOGY, vol. 43, no. 2, 21 December 2012 (2012-12-21), pages 200 - 204, XP055332772
"Stereochemistry of Carbon Compounds", 1994, JOHN WILEY & SONS, INC., pages: 1119 - 1190
JUNMIN ZHENG: "The Handbook of Pharmaceutical Excipients", CHEMISTRY INDUSTRY PRESS
"The Handbook of Commonly Used Pharmaceutical Excipients", THE SECOND MILITARY MEDICAL UNIVERSITY PRESS
"Pharmaceutical Excipients Daquan", SICHUAN SCIENCE & TECHNOLOGY PRESS
See also references of EP 3056206A4
ZHAO, QIONG ET AL.: "Spared Pre-irradiated Area in Pustular Lesions Induced by Icotinib Showing Decreased Expressions of CD 1a+ Langerhans Cells and FGFR2.", JAPANESE JOURNAL OF CLINICAL ONCOLOGY, vol. 43, no. 2, 21 December 2012 (2012-12-21), pages 200 - 204, XP055332772
"Stereochemistry of Carbon Compounds", 1994, JOHN WILEY & SONS, INC., pages: 1119 - 1190
JUNMIN ZHENG: "The Handbook of Pharmaceutical Excipients", CHEMISTRY INDUSTRY PRESS
"The Handbook of Commonly Used Pharmaceutical Excipients", THE SECOND MILITARY MEDICAL UNIVERSITY PRESS
"Pharmaceutical Excipients Daquan", SICHUAN SCIENCE & TECHNOLOGY PRESS
See also references of EP 3056206A4
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