Title:
SYNTHETIC INTERMEDIATE OF MAXACALCITOL, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/051762
Kind Code:
A1
Abstract:
The present invention provides a new method for synthesizing maxacalcitol and an intermediate thereof. According to the method, the maxacalcitol is creatively synthesized through the steps of: taking vitamin D2 as an initial raw material, obtaining a compound represented by formula II, oxidizing, chirally reducing, grafting with a side chain, introducing a hydroxyl group on the C-1 position, and photochemically overturning.
Inventors:
ZHENG GUOJUN (CN)
WANG YAPING (CN)
FENG SHI (CN)
WANG YAPING (CN)
FENG SHI (CN)
Application Number:
PCT/CN2014/088336
Publication Date:
April 16, 2015
Filing Date:
October 11, 2014
Export Citation:
Assignee:
ZHEJIANG HISUN PHARM CO LTD (CN)
International Classes:
C07D333/72; C07F7/18
Domestic Patent References:
| WO2012122451A2 | 2012-09-13 | |||
| WO2012122451A2 | 2012-09-13 | |||
| WO2001079166A1 | 2001-10-25 |
Foreign References:
| CN103508999A | 2014-01-15 | |||
| JP2011157326A | 2011-08-18 | |||
| CN102796134A | 2012-11-28 | |||
| US5436401A | 1995-07-25 | |||
| CN102796134A | 2012-11-28 | |||
| JPH021B2 | 1990-01-05 | |||
| US4866048A | 1989-09-12 |
Other References:
FENG, SHI ET AL.: "Improved and Efficient Synthesis of Maxacalcitol", CHINESE CHEMICAL LETTERS, vol. 25, no. 5, 31 May 2014 (2014-05-31), pages 774, XP029023917
See also references of EP 3056491A4
See also references of EP 3056491A4
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
上海弼兴律师事务所 (CN)
上海弼兴律师事务所 (CN)
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