Title:
IL13RA2-TARGETING HERPES SIMPLEX VIRUS AND ANTI-IL13RA2 ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/071397
Kind Code:
A1
Abstract:
The present invention provides an IL13RA2-targeting herpes simplex virus in which an anti-IL13RA2 antibody or an antigen-binding fragment thereof is presented on the viral surface. Also provided is an anti-IL13RA2 antibody or an antigen-binding fragment thereof capable of specifically recognizing tumor cells.
Inventors:
UCHIDA HIROAKI (JP)
TAHARA HIDEAKI (JP)
TAHARA HIDEAKI (JP)
Application Number:
PCT/JP2023/035689
Publication Date:
April 04, 2024
Filing Date:
September 29, 2023
Export Citation:
Assignee:
UNIV TOKYO (JP)
UCHIDA HIROAKI (JP)
UCHIDA HIROAKI (JP)
International Classes:
C12N7/01; A61K35/763; A61K39/395; A61P35/00; A61P35/02; C07K16/28; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13; C12N15/38; C12P21/08
Domestic Patent References:
| WO2021041725A1 | 2021-03-04 | |||
| WO2020090871A1 | 2020-05-07 |
Foreign References:
| JP2016503295A | 2016-02-04 |
Other References:
HIROAKI UCHIDA, MARCO MARZULLI, KENJI NAKANO, WILLIAM F GOINS, JANET CHAN, CHANG-SOOK HONG, LUCIA MAZZACURATI, JI YOUNG YOO, AMY H: "Effective Treatment of an Orthotopic Xenograft Model of Human Glioblastoma Using an EGFR-retargeted Oncolytic Herpes Simplex Virus", MOLECULAR THERAPY, ELSEVIER INC., US, vol. 21, no. 3, 1 March 2013 (2013-03-01), US , pages 561 - 569, XP055239489, ISSN: 1525-0016, DOI: 10.1038/mt.2012.211
FUKUHARA, TAKESHI ET AL.: "IL13Ra2, therapeutic target of melanoma, identified by unique targeted antibody screening technology", PROGRAMS AND LECTURE ABSTRACTS OF THE 86TH ANNUAL MEETING OF THE JAPANESE BIOCHEMICAL SOCIETY, 3T19a-11 (3LBA-057), 2013
FUKUHARA, TAKESHI ET AL.: "IL13Ra2, therapeutic target of melanoma, identified by unique targeted antibody screening technology", PROGRAMS AND LECTURE ABSTRACTS OF THE 86TH ANNUAL MEETING OF THE JAPANESE BIOCHEMICAL SOCIETY, 3T19a-11 (3LBA-057), 2013
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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