Title:
IMMUNE ADJUVANT BASED ON METALLOTHIONEIN FAMILY AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/236726
Kind Code:
A1
Abstract:
Disclosed is use of a metallothionein as an immune adjuvant. The use of the metallothionein with an immunogenic antigen in the form of a fusion protein or a composition can quickly, efficiently, and permanently excite an antigen-specific immune response.
Inventors:
CHEN WEI (CN)
YIN YING (CN)
XU JUNJIE (CN)
ZAI XIAODONG (CN)
YU RUI (CN)
GU YANFEI (CN)
ZHANG JUN (CN)
YIN YING (CN)
XU JUNJIE (CN)
ZAI XIAODONG (CN)
YU RUI (CN)
GU YANFEI (CN)
ZHANG JUN (CN)
Application Number:
PCT/CN2023/094092
Publication Date:
December 14, 2023
Filing Date:
May 13, 2023
Export Citation:
Assignee:
ACAD OF MILITARY MEDICAL SCIENCE PLA (CN)
International Classes:
A61K39/39; A61K39/02; A61K39/08; A61K39/215; A61P31/04; A61P31/14; A61P37/04; C07K19/00; C12N15/62; C12N15/70
Domestic Patent References:
| WO2021219047A1 | 2021-11-04 | |||
| WO2022002180A1 | 2022-01-06 |
Foreign References:
| CN114699521A | 2022-07-05 | |||
| CN114716571A | 2022-07-08 | |||
| CN112574318A | 2021-03-30 | |||
| CN1374871A | 2002-10-16 | |||
| US20030007973A1 | 2003-01-09 | |||
| US20100166759A1 | 2010-07-01 |
Other References:
YIN YING, GU YANFEI, ZAI XIAODONG, LI RUIHUA, ZHU XINJIE, YU RUI, ZHANG JUN, WANG SHUYI, ZHANG YUE, LIN JIAN, XU JUNJIE, CHEN WEI: "A novel built-in adjuvant metallothionein-3 aids protein antigens to induce rapid, robust, and durable immune responses", FRONTIERS IN IMMUNOLOGY, FRONTIERS MEDIA, LAUSANNE, CH, vol. 13, Lausanne, CH , XP093114454, ISSN: 1664-3224, DOI: 10.3389/fimmu.2022.1024437
CHENG, ZHONGGANG ET AL.: "The Immune Mechanism of Sea Cucumber and The Impacts of Immunostimulants", PIGS TODAY, no. 1, 15 January 2011 (2011-01-15), pages 17 - 22
CHENG, ZHONGGANG ET AL.: "The Immune Mechanism of Sea Cucumber and The Impacts of Immunostimulants", PIGS TODAY, no. 1, 15 January 2011 (2011-01-15), pages 17 - 22
Attorney, Agent or Firm:
BEIJING ZHONGTIAN LAWFIRM (CN)
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