Title:
IMMUNO-PET USING 89ZR-LABELED ANTI-CD25 ANTIBODIES
Document Type and Number:
WIPO Patent Application WO/2024/034759
Kind Code:
A1
Abstract:
The present invention relates to: an imaging agent of a PET-based imaging method, the agent comprising 89Zr-labeled anti-CD25 antibodies; and a tumor imaging method or tumor-infiltrating regulatory T cell imaging method using same. The unique 89Zr-labeled anti-CD25 antibodies according to the present invention exhibit a very high uptake rate, specifically in tissue in which CD25 antigens are present, and especially in portions in which lymphomas or regulatory T cells are present, and therefore can be effectively used as an effective non-invasive imaging agent capable of identifying, diagnosing, imaging, and monitoring lymphomas and/or regulatory T cells.
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Inventors:
LEE KYUNG-HAN (KR)
JUNG KYUNG-HO (KR)
LEE JIN HEE (KR)
JUNG KYUNG-HO (KR)
LEE JIN HEE (KR)
Application Number:
PCT/KR2023/002337
Publication Date:
February 15, 2024
Filing Date:
February 17, 2023
Export Citation:
Assignee:
RESEARCH ＆ BUSINESS FOUNDATION SUNGKYUNKWAN UNIV (KR)
SAMSUNG LIFE PUBLIC WELFARE FOUNDATION (KR)
SAMSUNG LIFE PUBLIC WELFARE FOUNDATION (KR)
International Classes:
A61K51/10
Domestic Patent References:
| WO2015153772A2 | 2015-10-08 | |||
| WO2021113450A2 | 2021-06-10 | |||
| WO2004110390A2 | 2004-12-23 |
Foreign References:
| US10905784B2 | 2021-02-02 | |||
| KR20220093103A | 2022-07-05 |
Other References:
LEE, K. H.: "Site-specific 89Zr-CD25 and PD-1 IgG for Immuno-PET of Lymphomas", A3 FORESIGHT PROGRAM SYMPOSIUM 2022, 27 February 2022 (2022-02-27), pages 1 - 4
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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