IMMUNOEVASIVE ANTI-TUMOR ADENOVIRUS

WIPO Patent Application WO/2023/120762

A1

The present invention relates to an anti-tumor adenovirus that can evade the in-vivo immune system. The adenovirus having high ability to kill tumor of the present invention, by comprising a nucleic acid encoding a transferrin binding moiety, has significantly increased effects of infecting and killing tumor cells, exhibits an increase in binding with transferrin to thereby evade in-vivo immune responses, leading to an increase in plasma half-life, is specifically delivered to cancer cells to produce systemic therapeutic effects, and can be topically delivered and has excellent selectivity, resulting in a remarkable effect in anti-tumor efficacy and, therefore, the adenovirus can be advantageously used as an anticancer composition or anticancer adjuvant in various types of cancer.

LEE WAN (KR)
YOO JUNG KI (KR)
UM KI HWAN (KR)
KIM MI SOON (KR)
CHOI JIN WOO (KR)

PCT/KR2021/019511

June 29, 2023

December 21, 2021

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CURIGIN CO LTD (KR)

C12N15/86; A61K48/00; A61P35/00

KR20160145825A	2016-12-20
KR20210119900A	2021-10-06
KR20020013464A	2002-02-20

JEONG IN-SIL: "Transferrine peptide ligand - Investigation of gene delivery efficiency into neural progenitor cells using an improved adenovirus.", MISAINMURHAG HOIJI - THE KOREAN JOURNAL OF MICROBIOLOGY, HANGUG MISAINMURHAG HOI, SEOUL, KR, vol. 42, no. 1, 1 March 2006 (2006-03-01), KR , pages 736 - 76, XP093073720, ISSN: 0440-2413
DATABASE GenBank NCBI; ANONYMOUS : "Neisseria meningitidis strain FDAARGOS_210 chromosome, complete genome", XP093073727
DATABASE GenBank NCBI; ANONYMOUS : "transferrin-binding protein TbpA [Neisseria meningitidis]", XP093073731

WIE, Byoung-Gap (KR)

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