Title:
IMPLANT AND METHOD FOR THE MANUFACTURE THEREOF
Document Type and Number:
WIPO Patent Application WO/2009/106502
Kind Code:
A3
Abstract:
What is described is an implant that comprises a coating, at least in areas, in the implanted state in the surface areas that are at least directly in contact with skin and/or soft tissue. The implant is preferably characterized in that the coating comprises both a statin, such as simvastatin, in the hydrolyzed or unhydrolyzed form, or pharmaceutically compatible salts thereof, as well as at least one other component selected from the group consisting of branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl, alkenyl, alkylaryl, aryl, cycloalkyl, alkylcycloalkyl, alkylcycloaryl amines or mixtures thereof and/or at least one water-soluble ionic polymer component. A method for production such an implant is also described as well as a composition that can be used in such a method.
Inventors:
SCHNABELRAUCH MATTHIAS (DE)
KAUTZ ARMIN REX (DE)
SCHLOTTIG FALKO (CH)
KAUTZ ARMIN REX (DE)
SCHLOTTIG FALKO (CH)
Application Number:
PCT/EP2009/052112
Publication Date:
July 01, 2010
Filing Date:
February 23, 2009
Export Citation:
Assignee:
THOMMEN MEDICAL AG (CH)
SCHNABELRAUCH MATTHIAS (DE)
KAUTZ ARMIN REX (DE)
SCHLOTTIG FALKO (CH)
SCHNABELRAUCH MATTHIAS (DE)
KAUTZ ARMIN REX (DE)
SCHLOTTIG FALKO (CH)
International Classes:
A61L27/34; A61K31/366; A61K47/48
Domestic Patent References:
| WO2007048264A1 | 2007-05-03 | |||
| WO2003105731A1 | 2003-12-24 | |||
| WO2006082500A1 | 2006-08-10 | |||
| WO2004091626A1 | 2004-10-28 |
Foreign References:
| EP1159934A2 | 2001-12-05 | |||
| US20070048351A1 | 2007-03-01 | |||
| US20040247673A1 | 2004-12-09 | |||
| DE20122679U1 | 2007-03-01 |
Other References:
ISMAIL FATMA A: "Design and in vitro evaluation of polymeric formulae of simvastatin for local bone induction", DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, NEW YORK, NY, US LNKD- DOI:10.1080/03639040600751886, vol. 32, no. 10, 1 November 2006 (2006-11-01), pages 1199 - 1206, XP009090743, ISSN: 0363-9045
Attorney, Agent or Firm:
BREMI, Tobias (Postfach 1772, Zürich, CH)
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