Title:
IMPROVED LOW-TOXICITY AND HIGHLY EFFICIENT PHARMACEUTICAL EXCIPIENT OF ORTHOESTER MIXTURE, METHOD FOR PREPARING SAME, AND LOCAL SUSTAINED-RELEASE PREPARATION COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2023/221320
Kind Code:
A1
Abstract:
The present invention relates to the field of pharmaceutical excipients, and particularly, to an improved low-toxicity and highly efficient pharmaceutical excipient of an orthoester mixture, a method for preparing same, and a local sustained-release preparation comprising same. The pharmaceutical excipient mainly comprises non-methoxy orthoester compounds (type I and type II) that are mixed in different ratios, or an orthoester compound (type I or type II) and a biocompatible medical macromolecular material that are mixed in different ratios. The type I orthoester compound is represented by chemical formula I, and the type II orthoester compound is represented by chemical formula II. The present invention further provides a method for preparing the pharmaceutical excipient, and a local sustained-release preparation comprising the excipient. The present invention has the beneficial effects of improving the biological safety of the pharmaceutical excipient by adjusting the type and length of substituents of the orthoester compound without changing the properties of the pharmaceutical excipient of the orthoester mixture before and after improvement, including, but not limited to, all of the functions and effects of the pharmaceutical excipient of the orthoester mixture before structural improvement.
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Inventors:
TANG RUPEI (CN)
YAN GUOQING (CN)
WANG XIN (CN)
YAN GUOQING (CN)
WANG XIN (CN)
Application Number:
PCT/CN2022/114445
Publication Date:
November 23, 2023
Filing Date:
August 24, 2022
Export Citation:
Assignee:
UNIV ANHUI (CN)
International Classes:
A61K9/06; A61K45/00; A61K47/10; A61K47/22; A61K47/32; A61K47/34; C07D317/34
Foreign References:
| CN114848585A | 2022-08-05 | |||
| CN114366711A | 2022-04-19 | |||
| CN103804339A | 2014-05-21 | |||
| US6166137A | 2000-12-26 |
Other References:
ZHUYONG WANG, YAJUN CHEN, ZIJIAN ZHANG, JIANLONG W U, ZHENLI MIN: "Application Progress of Prodrug for the Research of the Targeted Antitumor Drugs", CHINESE JOURNAL OF MODERN APPLIED PHARMACY, vol. 38, no. 18, 28 September 2021 (2021-09-28), pages 2323 - 2332, XP093110769, DOI: 10.13748/j.cnki.issn1007-7693.2021.18.020
TUTTLE TELL, CERKOVNIK JANEZ, PLESNIČAR BOŽO, CREMER DIETER: "Hemiortho Esters and Hydrotrioxides as the Primary Products in the Low-Temperature Ozonation of Cyclic Acetals: An Experimental and Theoretical Investigation", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 126, no. 49, 1 December 2004 (2004-12-01), pages 16093 - 16104, XP093110774, ISSN: 0002-7863, DOI: 10.1021/ja0450511
TUTTLE TELL, CERKOVNIK JANEZ, PLESNIČAR BOŽO, CREMER DIETER: "Hemiortho Esters and Hydrotrioxides as the Primary Products in the Low-Temperature Ozonation of Cyclic Acetals: An Experimental and Theoretical Investigation", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 126, no. 49, 1 December 2004 (2004-12-01), pages 16093 - 16104, XP093110774, ISSN: 0002-7863, DOI: 10.1021/ja0450511
Attorney, Agent or Firm:
HEFEI CITY, HAO ZHI YUN PATENTAGENCY (CN)
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