Title:
IMPROVED METHOD FOR MANUFACTURING MICRONEEDLE-BASED DIAGNOSTIC SKIN PATCH COATED WITH APTAMER, AND PATCH
Document Type and Number:
WIPO Patent Application WO/2020/235697
Kind Code:
A1
Abstract:
The present invention relates to a method for manufacturing a microneedle-based diagnostic skin patch coated with an aptamer, the method comprising a step for treating the surface of a microneedle with a base to modify the surface with a carboxyl group, and binding an aptamer having an amine group. A patch according to the present invention is advantageous in that a large number of aptamers, which are much smaller in size than antibody materials, can be attached to a relatively large number of microneedle tip surfaces. In addition, since aptamers for various kinds of biomarkers can be attached at the same time, various kinds of materials can be detected simultaneously (multiplexing), and thus even a microneedle tip-based skin patch can be used as a protein chip using aptamers.
Inventors:
SON IN SIK (KR)
Application Number:
PCT/KR2019/005921
Publication Date:
November 26, 2020
Filing Date:
May 17, 2019
Export Citation:
Assignee:
NEXMOS CO LTD (KR)
International Classes:
G01N33/543; A61B5/00; A61B10/02; G01N33/548
Domestic Patent References:
| WO2018124327A1 | 2018-07-05 |
Foreign References:
| KR20130104820A | 2013-09-25 | |||
| KR20100045831A | 2010-05-04 | |||
| KR20170017266A | 2017-02-15 | |||
| KR20160090096A | 2016-07-29 |
Attorney, Agent or Firm:
KOO, Hyun Seo (KR)
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