Title:
INDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND THEIR USE FOR MEDIATING OR INHIBITING CELL PROLIFERATION
Document Type and Number:
WIPO Patent Application WO2001053268
Kind Code:
B1
Abstract:
Indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating , e.g., kinases-dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
Inventors:
REICH SIEGFRIED HEINZ
BLECKMAN TED MICHAEL
KEPHART SUSAN ELIZABETH
ROMINES WILLIAM HENRY III
WALLACE MICHAEL B
BLECKMAN TED MICHAEL
KEPHART SUSAN ELIZABETH
ROMINES WILLIAM HENRY III
WALLACE MICHAEL B
Application Number:
PCT/US2001/001477
Publication Date:
January 24, 2002
Filing Date:
January 18, 2001
Export Citation:
Assignee:
AGOURON PHARMA (US)
International Classes:
A61K31/416; A61K31/4184; A61K31/4375; A61K31/443; A61K31/4439; A61K31/454; A61K31/4709; A61K31/4725; A61K31/5377; A61P9/00; A61P35/00; A61P43/00; B22D41/50; B22D11/10; B22D41/56; C07D231/56; C07D401/04; C07D401/14; C07D403/04; C07D403/14; C07D471/04; C07D521/00; (IPC1-7): C07D231/56; C07D403/04; C07D401/04; C07D401/14; C07D403/14; C07D401/10; C07D471/04; A61K31/416; A61K31/4184; A61K31/4439; A61P35/00
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