Title:
INDOLE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1998/015530
Kind Code:
A1
Abstract:
Novel indole derivatives represented by general formula (V) or pharmaceutically acceptable salts thereof. Because of having hypoglycemic or PDE5-inhibitory activities, these compouds or salts thereof are useful as remedies for impaired glucose tolerance, diabetes, complication of diabetes, insulin resistant syndrome, hyperlipidemia, atherosclerosis, cardiovascular diseases, hyper glycemia, hypertension; diseases characterized by angina pectoris, high blood pressure, pulmonary hypertension, congestive heart failure, glomerular diseases, tubular interstitial diseases, renal insufficiency, atherosclerosis, angiostenosis, peripheral vascular diseases, cerebral stroke, chronic reversible obstructive diseases, allergic rhinitis, urticaria, glaucoma or intestinal motility disorders; sexual impotence, complication of diabetes, osteoporosis, nephritis, cancerous cachexia or post-PTCA reconstriction, wherein R�13? to R�15? represent each: 1) hydrogen, 2) lower alkyl, lower alkylthio or lower alkoxy-substituted lower alkyl, or 3) lower alkyl, hydroxy, hydroxylated lower alkyl, lower alkyloxy, etc. bonded to or substituted by aryl or a heterocycle; provided that R�13? to R�15? do not represent hydrogen at the same time; R�16? represents: 1) hydrogen, or 2) lower alkyl; and R�17? represents optionally esterified carboxy.
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Inventors:
YAMASAKI NORITSUGU (JP)
IMOTO TAKAFUMI (JP)
MURAI YOSHIYUKI (JP)
HIRAMURA TAKAHIRO (JP)
ONOMURA OSAMU (JP)
NISHIKAWA MASAHIRO (JP)
OKU TERUO (JP)
SAWADA KOUZOU (JP)
KAYAKIRI HIROSHI (JP)
IMOTO TAKAFUMI (JP)
MURAI YOSHIYUKI (JP)
HIRAMURA TAKAHIRO (JP)
ONOMURA OSAMU (JP)
NISHIKAWA MASAHIRO (JP)
OKU TERUO (JP)
SAWADA KOUZOU (JP)
KAYAKIRI HIROSHI (JP)
Application Number:
PCT/JP1997/003592
Publication Date:
April 16, 1998
Filing Date:
October 07, 1997
Export Citation:
Assignee:
FUJISAWA PHARMACEUTICAL CO (JP)
YAMASAKI NORITSUGU (JP)
IMOTO TAKAFUMI (JP)
MURAI YOSHIYUKI (JP)
HIRAMURA TAKAHIRO (JP)
ONOMURA OSAMU (JP)
NISHIKAWA MASAHIRO (JP)
OKU TERUO (JP)
SAWADA KOUZOU (JP)
KAYAKIRI HIROSHI (JP)
YAMASAKI NORITSUGU (JP)
IMOTO TAKAFUMI (JP)
MURAI YOSHIYUKI (JP)
HIRAMURA TAKAHIRO (JP)
ONOMURA OSAMU (JP)
NISHIKAWA MASAHIRO (JP)
OKU TERUO (JP)
SAWADA KOUZOU (JP)
KAYAKIRI HIROSHI (JP)
International Classes:
C07D209/08; C07D401/06; C07D401/12; C07D403/06; C07D403/12; C07D405/06; C07D405/12; C07D417/06; C07D417/10; C07D417/12; C07D417/14; (IPC1-7): C07D209/08; A61K31/40; A61K31/425; A61K31/44; A61K31/475; C07D209/10; C07D209/12; C07D401/06; C07D401/12; C07D417/06
Domestic Patent References:
| WO1995016687A1 | 1995-06-22 | |||
| WO1996003377A1 | 1996-02-08 |
Foreign References:
| JPH05345778A | 1993-12-27 | |||
| JPH08208602A | 1996-08-13 | |||
| JPH04230661A | 1992-08-19 | |||
| JPH0710839A | 1995-01-13 | |||
| JPS62153271A | 1987-07-08 | |||
| JPH0641068A | 1994-02-15 | |||
| JPH04266870A | 1992-09-22 | |||
| JPH09176162A | 1997-07-08 |
Attorney, Agent or Firm:
Shimizu, Hatsushi (1-1-1 Oroshi-mach, Tsuchiura-shi Ibaraki 300, JP)
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