Title:
PROCESS FOR PREPARING ACID SALTS OF $g(g)-(PIPERIDYL)BUTYRIC ACID
Document Type and Number:
WIPO Patent Application WO/1998/015531
Kind Code:
A1
Abstract:
A process for preparing acid salts (2) of $g(g)-(piperidyl)butyric acid by hydrogenating an acid salt (1) of $g(g)-(pyridyl)butyric acid (preferably, one prepared through the following steps (a) and (b) and having a content of acid salts (3) of bis(pyridylethyl)acetic acid of not more than 3 % by weight) in a solvent in the presence of a catalyst, wherein a rhodium, palladium or ruthenium catalyst is used as the catalyst. Step (a): a vinylpyridine compound (4) is reacted with a diester (5) of malonic acid in the presence of a base to prepare a diester (6) of 2-(pyridylethyl)malonic acid. Step (b): the diester (6) prepared in the step (a) is hydrolyzed and decarboxylated in an aqueous acid solution to prepare the acid salt (1) of $g(g)-(pyridyl)butyric acid.
Inventors:
SAKAI TOSHITO (JP)
NAGAOKA MASAYO (JP)
KANNO KEN (JP)
NAGAOKA MASAYO (JP)
KANNO KEN (JP)
Application Number:
PCT/JP1997/003594
Publication Date:
April 16, 1998
Filing Date:
October 07, 1997
Export Citation:
Assignee:
KOEI CHEMICAL CO (JP)
SAKAI TOSHITO (JP)
NAGAOKA MASAYO (JP)
KANNO KEN (JP)
SAKAI TOSHITO (JP)
NAGAOKA MASAYO (JP)
KANNO KEN (JP)
International Classes:
C07D211/34; C07D213/55; (IPC1-7): C07D211/34; C07D213/55; B01J23/56
Foreign References:
| EP0718287A2 | 1996-06-26 | |||
| JPS57193456A | 1982-11-27 |
Other References:
CHEMICAL ABSTRACTS, Vol. 58, No. 9, 29 April 1963, MIKHLINA E.E. et al., "Synthesis of 1-Azabicyclo(3.2.2)Nonane-2-Carboxylic Acid"; & ZH. OBSHCH. KHIM., 1962, Vol. 32, p. 2177-2184.
See also references of EP 0882712A4
See also references of EP 0882712A4
Attorney, Agent or Firm:
Saegusa, Eiji (1-7-1 Dosho-machi, Chuo-k, Osaka-shi Osaka 541, JP)
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