Title:
INDOLINE DERIVATIVE AND CYTOTOXIC AGENT CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2019/004413
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel duocarmycin derivative which has a functional group at position-7 in a 1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzo[e]indol backbone wherein the position-7 corresponds to position-6 in a 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one backbone, and which has high cytotoxicity. The present invention provides an indoline derivative typified by the formula or a pharmacologically acceptable salt thereof.
Inventors:
NISHIO YUKIHIRO (JP)
NAGAHARA TAKASHI (JP)
NAGAHARA TAKASHI (JP)
Application Number:
PCT/JP2018/024762
Publication Date:
January 03, 2019
Filing Date:
June 29, 2018
Export Citation:
Assignee:
TORAY INDUSTRIES (JP)
International Classes:
C07D209/60; A61K31/404; A61P43/00; A61P35/00
Domestic Patent References:
| WO2009017394A1 | 2009-02-05 | |||
| WO2004101767A2 | 2004-11-25 |
Foreign References:
| JP2008517905A | 2008-05-29 | |||
| JP2004522779A | 2004-07-29 |
Other References:
BOGER, DALE L. ET AL.: "Synthesis, Chemical Properties, and Biological Evaluation of CC-1065 and Duocarmycin Analogues Incorporating the 5-Methoxycarbonyl-1, 2, 9, 9a- tetrahydrocyclopropa[c]benz[e]ind ol-4-one Alkylation Subunit", JOURNAL OF ORGANIC CHEMISTRY, vol. 66, no. 7, 13 March 2001 (2001-03-13), pages 2207 - 2216, XP055677572, ISSN: 0022-3263, DOI: 10.1021/jo001772g
TIETZE, LUTZ F. ET AL.: "Synthesis of a Novel Pentagastrin- Drug Conjugate for a Targeted Tumor Therapy", CHEMISTRY-A EUROPEAN JOURNAL, vol. 14, no. 9, 2008, pages 2811 - 2818, XP002495967, ISSN: 0947-6539, DOI: 10.1002/chem.200701521
TIETZE, LUTZ F. ET AL.: "Synthesis and Biological Evaluation of a Novel Pentagastrin-Toxin Conjugate Designed for a Targeted Prodrug Monotherapy of Cancer", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 9, no. 5, 20 May 2008 (2008-05-20), pages 821 - 837, XP055677576, ISSN: 1422-0067, DOI: 10.3390/ijms9050821
GHOSH, NANDI ET AL.: "Chemical and Biological Explorations of the Family of CC-1065 and the Duocarmycin Natural Products", CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 9, no. 16, November 2009 (2009-11-01), pages 1494 - 1524, XP055677579, ISSN: 1568-0266, DOI: 10.2174/156802609789909812
TIETZE, LUTZ F. ET AL.: "Synthesis of a Novel Pentagastrin- Drug Conjugate for a Targeted Tumor Therapy", CHEMISTRY-A EUROPEAN JOURNAL, vol. 14, no. 9, 2008, pages 2811 - 2818, XP002495967, ISSN: 0947-6539, DOI: 10.1002/chem.200701521
TIETZE, LUTZ F. ET AL.: "Synthesis and Biological Evaluation of a Novel Pentagastrin-Toxin Conjugate Designed for a Targeted Prodrug Monotherapy of Cancer", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 9, no. 5, 20 May 2008 (2008-05-20), pages 821 - 837, XP055677576, ISSN: 1422-0067, DOI: 10.3390/ijms9050821
GHOSH, NANDI ET AL.: "Chemical and Biological Explorations of the Family of CC-1065 and the Duocarmycin Natural Products", CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 9, no. 16, November 2009 (2009-11-01), pages 1494 - 1524, XP055677579, ISSN: 1568-0266, DOI: 10.2174/156802609789909812
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