Title:
INDUCED ACTIVATION IN DENDRITIC CELLS
Document Type and Number:
WIPO Patent Application WO2004073641
Kind Code:
A3
Abstract:
The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. More particularly, the present invention is drawn to compositions that are based on dendritic cells modified to express an inducible form of a costimulatory polypeptide.
Inventors:
SLAWIN KEVIN (US)
SPENCER DAVID (US)
HANKS BRENT (US)
SPENCER DAVID (US)
HANKS BRENT (US)
Application Number:
PCT/US2004/004757
Publication Date:
March 24, 2005
Filing Date:
February 18, 2004
Export Citation:
Assignee:
SLAWIN KEVIN (US)
SPENCER DAVID (US)
HANKS BRENT (US)
SPENCER DAVID (US)
HANKS BRENT (US)
International Classes:
A61K38/00; A61K38/17; A61K39/00; A61K39/12; A61K48/00; C12N15/74; A61K; (IPC1-7): C12N15/74; A61K38/00; A61K48/00
Other References:
CHIODONI C. ET AL.: "Dendritic cells infiltrating tumors cotransuced with GM-CSF and CD40 ligand take up and present endogenous tumor-associated antigens, and prime naive mice for a CTL response", J. EXP. MED., vol. 190, 1999, pages 125 - 133, XP002308453
RIVERA V.: "Controlling gene expression using synthetic ligands", METHODS, vol. 14, 1998, pages 421 - 429, XP004466621
TONG ET AL.: "Prospects for CD40-directed experimental therapy of human cancer", CANCER GENE THER., vol. 10, 2003, pages 1 - 13, XP008042378
GRUIJL ET AL.: "Prolonged maturation and enhanced transduction of dendritic cells migrated from human skin explants after in situ delivery of CD40-targeted adenoviral vectors", J. IMMUNOL., vol. 169, 2002, pages 5322 - 5331, XP002983385
RICHARD R. ET AL.: "Expansion of genetically modified primary humanhemopoietic cells using chemical inducers of dimerization", BLOOD, vol. 95, 2000, pages 430 - 436, XP002983386
RIVERA V.: "Controlling gene expression using synthetic ligands", METHODS, vol. 14, 1998, pages 421 - 429, XP004466621
TONG ET AL.: "Prospects for CD40-directed experimental therapy of human cancer", CANCER GENE THER., vol. 10, 2003, pages 1 - 13, XP008042378
GRUIJL ET AL.: "Prolonged maturation and enhanced transduction of dendritic cells migrated from human skin explants after in situ delivery of CD40-targeted adenoviral vectors", J. IMMUNOL., vol. 169, 2002, pages 5322 - 5331, XP002983385
RICHARD R. ET AL.: "Expansion of genetically modified primary humanhemopoietic cells using chemical inducers of dimerization", BLOOD, vol. 95, 2000, pages 430 - 436, XP002983386
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