INHALATION ADMINISTRATION DELIVERY SYSTEM OF RECOMBINANT ADENOVIRUS VECTOR VACCINE

Title:

INHALATION ADMINISTRATION DELIVERY SYSTEM OF RECOMBINANT ADENOVIRUS VECTOR VACCINE

Document Type and Number:

WIPO Patent Application WO/2023/109740

Kind Code:

A1

Abstract:

Disclosed is an inhalation administration delivery system of a recombinant adenovirus vector vaccine. In the delivery system, an adenovirus vector is reformed and matched with a specific preparation prescription, and after being administered by means of inhalation, the vaccine can reach the lungs by means of nasal inhalation or mouth inhalation, so that a protective immune response including mucosal immunity is generated, the effective utilization rate of the vaccine is increased, the pre-existing immunity of an adenovirus is solved, and an effect of the vaccine is improved.

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Inventors:

SHAO JUAN (CN)
SUI XIUWEN (CN)
ZHOU CHAODONG (CN)
CAO LONGLONG (CN)
SU ZHE (CN)
MIAO WEI (CN)
WU DAN (CN)
WEI BOCHAO (CN)
XU FANG (CN)
SI WEIXUE (CN)
QI YUANYUAN (CN)
XI ZHIAI (CN)
ZHU TAO (CN)

Application Number:

PCT/CN2022/138331

Publication Date:

June 22, 2023

Filing Date:

December 12, 2022

Export Citation:

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Assignee:

CANSINO BIOLOGICS INC (CN)

International Classes:

A61K9/12; A61K35/761; A61K47/42; A61M11/00; A61P31/00; A61P31/14

Domestic Patent References:

WO2021194183A1

2021-09-30

Foreign References:

CN112451811A	2021-03-09
CN106471125A	2017-03-01
CN113750227A	2021-12-07

Other References:

ROJAS, L. ET AL.: "Albumin-binding adenoviruses circumvent pre-existing neutralizing antibodies upon systemic delivery", JOURNAL OF CONTROLLED RELEASE, vol. 237, 4 July 2016 (2016-07-04), XP029679989, DOI: 10.1016/j.jconrel.2016.07.004
MATO-BERCIANO, A. ET AL.: "Oncolytic adenovirus with hyaluronidase activity that evades neutralizing antibodies: VCN-11", JOURNAL OF CONTROLLED RELEASE, vol. 332, 3 March 2021 (2021-03-03), XP086558707, DOI: 10.1016/j.jconrel.2021.02.035

Attorney, Agent or Firm:

BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)

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