INHIBITION OF BEHAB CLEAVAGE AND PRIMARY CENTRAL NERVOUS SYSTEM (CNS) TUMORS

Title:

INHIBITION OF BEHAB CLEAVAGE AND PRIMARY CENTRAL NERVOUS SYSTEM (CNS) TUMORS

Document Type and Number:

WIPO Patent Application WO2003007880

Kind Code:

A3

Abstract:

The present invention relates to primary CNS tumors and provides useful compositions and methods for reducing tumor volume and increasing the length of survival in mammals with primary CNS tumors, thereby providing a treatment for primary CNS tumors. The invention also relates to methods of identifying compounds for reducing tumor volume and increasing animal survival, which therefore relate to treating primary CNS tumors.

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Inventors:

HOCKFIELD SUSAN (US)
MATTHEWS RUSSELL T (US)

Application Number:

PCT/US2002/022539

Publication Date:

July 10, 2003

Filing Date:

July 16, 2002

Export Citation:

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Assignee:

UNIV YALE (US)
HOCKFIELD SUSAN (US)
MATTHEWS RUSSELL T (US)

International Classes:

G01N33/50; A61K31/7088; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P25/00; A61P25/28; A61P35/00; A61P35/04; C07K14/47; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N5/22; C12N15/09; C12N15/12; C12P21/08; C12Q1/68; G01N33/15; G01N33/53; (IPC1-7): C07H21/02; C12N1/20; C12N15/12; C12N15/63

Other References:

DATABASE GENBANK [online] YAMADA ET AL.: "CDNA cloning and the identification of an aggrecanase-like cleavage site in rat brevican", XP002963805, Database accession no. (RNU37142)
See also references of EP 1417217A4

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