Title:
INHIBITORS OF HUMAN RHINOVIRUS 2A CYSTEINE PROTEASE
Document Type and Number:
WIPO Patent Application WO2002088091
Kind Code:
A3
Abstract:
Compounds of formula I are effective inhibitors of human rhinovirus 2A protease: (I) where R1 is H, lower alkyl, lower alkenyl, lower alkynyl, lower acyl, or lower acyloxy, substituted with 0-3 substituents selected from the group consisting of OH, halo, amino, nitro; R2 is H, lower alkyl, OH, halo, or amino; R3, R4, R5, R6, and R7 are each independently H, halo, OH, amino, nitro, lower alkyl, aryl, aralkyl, lower alkoxy, or lower alkylamino; or a pharmaceutically acceptable salt thereof.
Inventors:
KIM RAYMOND A (US)
SHIVAK DAVID (US)
SUN DONGXU (US)
SHIVAK DAVID (US)
SUN DONGXU (US)
Application Number:
PCT/US2002/013270
Publication Date:
December 19, 2002
Filing Date:
April 26, 2002
Export Citation:
Assignee:
ICONIX PHARM INC (US)
KIM RAYMOND A (US)
SHIVAK DAVID (US)
SUN DONGXU (US)
KIM RAYMOND A (US)
SHIVAK DAVID (US)
SUN DONGXU (US)
International Classes:
C07D231/22; C07D231/26; (IPC1-7): C07D231/22; C07D231/26
Other References:
DATABASE CAPLUS [online] TANAKA E. ET AL.: "Comparison of trimethadione and antipyrine as indicators of oxidative drug metabolizing capacity in man", XP002958361, accession no. STN Database accession no. 1989:508460
DATABASE CAPLUS [online] USUI Y. ET AL.: "Fungicides. XII. Synthesis and antifungal activity of halogen-substituted phenylpyrazolone derivatives", XP002958362, accession no. STN Database accession no. 1967:411452
DATABASE CAPLUS [online] USUI Y. ET AL.: "Fungicides. XII. Synthesis and antifungal activity of halogen-substituted phenylpyrazolone derivatives", XP002958362, accession no. STN Database accession no. 1967:411452
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