INHIBITORS OF MONOAMINE UPTAKE

Title:

INHIBITORS OF MONOAMINE UPTAKE

Document Type and Number:

WIPO Patent Application WO2004052858

Kind Code:

A3

Abstract:

N,N-disubstituted 4-amino-piperidines of the general Formula (I) are inhibitors of the uptake of serotonin and/or norepinephrine and/or dopamine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system.

Inventors:

CLARK BARRY PETER (GB)
CASES-THOMAS MANUEL JAVIER (GB)
GALLAGHER PETER THADDEUS (GB)
GILMORE JEREMY (GB)
MASTERS JOHN JOSEPH (US)
TIMMS GRAHAM HENRY (GB)
WHATTON MARIA ANN (GB)
WOOD VIRGINIA ANN (GB)

Application Number:

PCT/US2003/035972

Publication Date:

August 12, 2004

Filing Date:

November 25, 2003

Export Citation:

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Assignee:

LILLY CO ELI (US)
CLARK BARRY PETER (GB)
CASES-THOMAS MANUEL JAVIER (GB)
GALLAGHER PETER THADDEUS (GB)
GILMORE JEREMY (GB)
MASTERS JOHN JOSEPH (US)
TIMMS GRAHAM HENRY (GB)
WHATTON MARIA ANN (GB)
WOOD VIRGINIA ANN (GB)

International Classes:

A61P25/00; C07D211/58; C07D405/12; (IPC1-7): C07D211/58; C07D405/12; A61K31/44; A61P25/00

Domestic Patent References:

WO2004030668A1

2004-04-15

Foreign References:

US5869502A	1999-02-09
EP0026469A1	1981-04-08

Other References:

THOMAS RYCKMANS ET AL: "First Dual NK1 Antagonists-Serotonin Reuptake Inhibitors: synthesis and SAR of a New Class of Potential Antidepressants", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 12, no. 2, 2002, pages 261 - 264, XP002974382, ISSN: 0960-894X
CHEMICAL ABSTRACTS, vol. 105, no. 19, 10 November 1986, Columbus, Ohio, US; abstract no. 172295c, page 730; XP002011567

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