Title:
INHIBITORS OF UROKINASE AND BLOOD VESSEL FORMATION
Document Type and Number:
WIPO Patent Application WO2000005245
Kind Code:
A3
Abstract:
Novel compounds having activity inhibitors of urokinase and in reducing or inhibiting blood vessel formation are provided. These compounds have an arginine or arginine mimic aldehyde or an arginine ketoamide group at P1. These compounds are useful in vitro for monitoring plasminogen activator levels and in vivo in treatment of conditions which are ameliorated by inhibition of or decreased activity of urokinase and in treating pathologic conditions wherein blood vessel formation is related to a pathologic condition.
Inventors:
BRUNCK TERENCE K (US)
TAMURA SUSAN Y (US)
TAMURA SUSAN Y (US)
Application Number:
PCT/US1999/016577
Publication Date:
April 20, 2000
Filing Date:
July 22, 1999
Export Citation:
Assignee:
CORVAS INT INC (US)
BRUNCK TERENCE K (US)
TAMURA SUSAN Y (US)
BRUNCK TERENCE K (US)
TAMURA SUSAN Y (US)
International Classes:
C12N9/99; A61K38/00; A61P9/10; A61P17/06; A61P17/12; A61P19/08; A61P27/02; A61P29/00; A61P31/00; A61P35/00; A61P35/04; A61P43/00; C07K5/06; C07K5/068; C07K5/08; (IPC1-7): C07K5/062; C07K5/068; A61K38/04
Domestic Patent References:
| WO1994008941A1 | 1994-04-28 |
Foreign References:
| US5153176A | 1992-10-06 | |||
| US5508385A | 1996-04-16 |
Other References:
PATEL E.A.: "Transition-state affinity chromatography of trypsin-like proteinases with dipeptidyl argininal ligands", BIOCHIM.BIOPHYS.ACTA, vol. 748, 1983, pages 321 - 330, XP002120735
BAJUSZ S ET AL: "DESIGN AND SYNTHESIS OF PEPTIDE INHIBITORS OF BLOOD COAGULATION", FOLIA HEMATOLOGY. INTERNATIONALES MAGAZIN FUER KLINISCHE UND EXPERIMENTELLE BLUTFORSCHUNG, vol. 109, no. 1, 1 January 1982 (1982-01-01), pages 16 - 21, XP000560955
OSTROWSKI E.A.: "Selective inhibition of proteolytic enzymes in an in vivo mouse model for experimental metastasis", CANCER RESEARCH, vol. 46, August 1986 (1986-08-01), pages 4121 - 4128, XP002120736
BAJUSZ S ET AL: "DESIGN AND SYNTHESIS OF PEPTIDE INHIBITORS OF BLOOD COAGULATION", FOLIA HEMATOLOGY. INTERNATIONALES MAGAZIN FUER KLINISCHE UND EXPERIMENTELLE BLUTFORSCHUNG, vol. 109, no. 1, 1 January 1982 (1982-01-01), pages 16 - 21, XP000560955
OSTROWSKI E.A.: "Selective inhibition of proteolytic enzymes in an in vivo mouse model for experimental metastasis", CANCER RESEARCH, vol. 46, August 1986 (1986-08-01), pages 4121 - 4128, XP002120736
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