Title:
INJECTABLE AQUEOUS FORMULATION FOR TREATING INFLAMMATORY AUTOIMMUNE DISEASES
Document Type and Number:
WIPO Patent Application WO/2015/147018
Kind Code:
A1
Abstract:
An injectable aqueous formulation for treating inflammatory autoimmune diseases contains methotrexate or a pharmaceutically acceptable salt of methotrexate such that the methotrexate concentration is 25 mg/mL-100 mg/mL, and also contains a buffer and a tonicity agent. The injectable aqueous formulation has a pH of 7.0-8.0, and the osmotic pressure ratio of the injectable aqueous formulation with respect to physiological saline is 0.9-1.1.
Inventors:
FUKUSHIMA SATOKO (JP)
NAKAMURA KOJI (JP)
AMI NOZOMI (JP)
YAGO SEIJI (JP)
NAKAMURA KOJI (JP)
AMI NOZOMI (JP)
YAGO SEIJI (JP)
Application Number:
PCT/JP2015/058993
Publication Date:
October 01, 2015
Filing Date:
March 24, 2015
Export Citation:
Assignee:
TERUMO CORP (JP)
International Classes:
A61K31/519; A61K9/08; A61M5/00; A61M5/28; A61M5/315; A61P29/00; A61P37/00
Foreign References:
| JP2009544636A | 2009-12-17 | |||
| JPH11222425A | 1999-08-17 | |||
| JP2010528045A | 2010-08-19 | |||
| JP2013526545A | 2013-06-24 | |||
| JP2006025953A | 2006-02-02 | |||
| JP2013192634A | 2013-09-30 |
Other References:
HANSEN J. ET AL.: "Kinetics of degradation of methotrexate in aqueous solution.", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 16, 1983, pages 141 - 152, XP023844715
Attorney, Agent or Firm:
MUKAIYAMA Shoichi (JP)
Shoichi Mukoyama (JP)
Shoichi Mukoyama (JP)
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