Title:
INJECTABLE METAL PEROXIDE COMPOUNDED HYDROGEL, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/082413
Kind Code:
A1
Abstract:
An injectable metal peroxide compounded hydrogel, and a preparation method therefor and the use thereof. The hydrogel is prepared by means of dissolving a modified high-molecular polymer, a metal peroxide and peroxidase in a solvent, uniformly mixing same and leaving same to stand, wherein the modified high-molecular polymer is a high-molecular polymer grafted with a phenolic hydroxyl group. The hydrogel is prepared by means of inducing the rapid crosslinking of a modified high-molecular polymer using a metal peroxide under the action of peroxidase. The hydrogel has good photothermal properties, antibacterial properties, tissue adhesion properties, osteogenic effect, shape adaptability and injectability, can be adapted to irregular bone defect areas, is used for repairing defects caused by tumor surgery by means of the synergistic effect of multiple functions, and can effectively prevent tumor recurrence and reduce the possibility of infection caused by implanted materials.
Inventors:
LAI YUXIAO (CN)
ZHANG WENJING (CN)
ZHANG WEI (CN)
LI CAIRONG (CN)
YAO ZHENYU (CN)
ZHANG WENJING (CN)
ZHANG WEI (CN)
LI CAIRONG (CN)
YAO ZHENYU (CN)
Application Number:
PCT/CN2021/138483
Publication Date:
May 19, 2023
Filing Date:
December 15, 2021
Export Citation:
Assignee:
SHENZHEN INST OF ADV TECH CAS (CN)
International Classes:
A61L27/16; A61L27/02; A61L27/20; A61L27/22; A61L27/24; A61L27/50; A61L27/52; A61L27/54; C08H1/00; C08J3/075; C08K3/18; C08L89/00
Foreign References:
| US20200230289A1 | 2020-07-23 | |||
| KR20210146691A | 2021-12-06 | |||
| US20160256604A1 | 2016-09-08 | |||
| US20190282731A1 | 2019-09-19 | |||
| JP2019202054A | 2019-11-28 | |||
| CN112316214A | 2021-02-05 | |||
| CN102573944A | 2012-07-11 | |||
| CN113577276A | 2021-11-02 | |||
| CN110343352A | 2019-10-18 | |||
| CN112604033A | 2021-04-06 |
Attorney, Agent or Firm:
BEIJING ZHONG XUN TONG DA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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