Title:
INSPECTION METHOD ENABLING SPECIFIC DIAGNOSIS OF PATHOLOGICAL STATE OF DIABETIC NEPHROPATHY AT EARLY STAGE
Document Type and Number:
WIPO Patent Application WO/2018/066409
Kind Code:
A1
Abstract:
Provided is an inspection method which enables specific diagnosis of the pathological state of diabetic nephropathy at an early stage. The method, which aims at the detection of the onset or onset risk of diabetic nephropathy, comprises measuring IgG4 in a biological sample derived from a subject. The inspection method may further comprise measuring Smad1 in the biological sample derived from the subject, said method preferably comprising measuring both.
More Like This:
Inventors:
DOI TOSHIO (JP)
TOMINAGA TATSUYA (JP)
ICHIEN GO (JP)
YAMAMOTO KEIICHI (JP)
TOMINAGA TATSUYA (JP)
ICHIEN GO (JP)
YAMAMOTO KEIICHI (JP)
Application Number:
PCT/JP2017/034699
Publication Date:
April 12, 2018
Filing Date:
September 26, 2017
Export Citation:
Assignee:
HUBIT GENOMIX INC (JP)
FUSO PHARMACEUTICAL IND (JP)
FUSO PHARMACEUTICAL IND (JP)
International Classes:
G01N33/68; C12Q1/68; G01N33/15; G01N33/493; G01N33/50; G01N33/53
Domestic Patent References:
| WO2016001215A2 | 2016-01-07 |
Foreign References:
| JPH09235228A | 1997-09-09 | |||
| JP5453420B2 | 2014-03-26 | |||
| JP3358819B2 | 2002-12-24 | |||
| JP2016195420A | 2016-11-17 |
Other References:
GAMBARDELLA S.: "Urinary IgG4; an additional parameter in characterizing patinets with incipient diabetic nephropathy", DIABETES RESEARCH, vol. 10, no. 4, April 1989 (1989-04-01), pages 153 - 157, XP009514911
NEGISHI, KIYOHIKO: "Urinary Total IgG and IgG4 Excretion in Non-Insulin-Dependent Diabetes Mellitus. Using a Sensitive Total IgG and IgG4 Assay.:Using a Sensitive Total IgG and IgG4 Assay", JOURNAL OF THE JAPAN DIABETES SOCIETY, vol. 35, no. 12, 1 December 1992 (1992-12-01), pages 1007 - 1011, XP055597288, DOI: 10.11213/tonyobyo1958.35.1007
MORANO S.: "URINARY IGGR4 AN ADDITIONAL PARAMETER IN CHARACTERIZED PATIENTS WITH STAGE III DIABETIC NEPHROPATHY", DIABETOLOGIA, vol. 30, no. 7, 1987, pages 559A 384, XP009514427, ISSN: 0012-186X
TOMINAGA, SHINYA: "Usefulness of Smadl in Urine in Diagnosis of Early-stage Nephropathy", JAPANESE JOURNAL OF MEDICAL TECHNOLOGY, vol. 54, no. 4, 25 April 2005 (2005-04-25), TOMINAGA, Shinya, pages 642 (344), XP009515680
TORFFVIT 0.: "Size and charge selectivity of the glomerular filter in patients with insulin-dependent diabetes mellitus: urinary immunogloblins and glycosaminoglycans", NEPHRON, vol. 83, no. 4, 1999, pages 301 - 307, XP009515263, DOI: 10.1159/000045421
MORANO S.: "The selective eliminations of anionic immunogloblins as a parameter of kidney damage in debetes and diabetic pregnancy", THE JOURNAL OF DEABETIC COMPLICATIONS, vol. 2, no. 1, 1988, pages 2 - 4, XP001087989
ISAO YASHIMA: "Diagnostic significance of urinary immunoglobulin G in diabetic nephropathy", JAPANESE JOURNAL OF NEPHROLOGY, vol. 41, no. 8, 25 December 1999 (1999-12-25), pages 787 - 796, XP009515265, DOI: 10.14842/jpnjnephrol1959.41.787
MOTOHIDE ISONO; MASAKAZU HANEDA; MASAKI TOGAWA; TSUTOMU SHIKANO; SHINNICHI ARAKI; TAKAHIKO NAKAGAWA; TAKERU ISHIDA; KEN INOKI; KEN: "Analysis of Urinary Type IV Collagen in NIDDM Subjects as a Marker for Diabetic Nephropathy", J. JAPAN DIAB. SOCI., vol. 39, 1996, pages 599 - 604
YASUHIKO IEKI; EISUKE TAKAZAKURA: "Significance of Measurement of Urinary Type IV Collagen as a Predictor of Progress of Early-Stage Diabetic Nephropathy", J. JAPAN DIAB. SOCI., vol. 42, 1999, pages 859 - 862
KIYOHIKO NEGISHI; SATOMI SHIBASAKI; YASUAKI ISHIMARU ET AL.: "Total Urinary IgG and IgG4 Excretion in Non-Insulin-Dependent Diabetes Mellitus - Using a Sensitive Total IgG and IgG4 Assay", J. JAPAN DIAB. SOC., vol. 35, 1992, pages 1007 - 1011
ISAO YASHIMA; TOSHIHIDE HIRAYAMA; HIDEO SHIIKI; MASAO KANAUCHI; KAZUHIRO DOHI: "Diagnostic significance of urinary immunoglobulin G in diabetic nephropathy", JPN J NEPHROL, vol. 41, 1999, pages 787 - 796
KROLEWSKI M; EGGERS PW; WARRAM JH: "Magnitude of end-stage renal disease in IDDM: a 35 year follow-up study", KIDNEY INT, vol. 50, 1996, pages 2041 - 2046
BOJESTIG M; AMQVIST HJ; HERMANSSON G; KARLBERG BE; LUDVIGSSON J: "Declining incidence of nephropathy in insulin-dependent diabetes mellitus", N ENGL J MED, vol. 330, 1994, pages 15 - 18
PARVING H-H; MAUER M; RITZ E: "Diabetic nephropathy", 2004, SAUNDERS, ELSEVIER'S HEALTH SCIENCES DEPARTMENT, pages: 1777 - 1818
MAUER SM; STEFFES MW; ELLIS EN; SUTHERLAND DE; BROWN DM; GOETZ FC: "Structural-functional relationships in diabetic nephropathy", J CLIN INVEST, vol. 74, 1984, pages 1143 - 1155
KRIZ W; LEHIR M: "Pathways to nephron loss starting from glomerular disease- Insights from animal models", KIDNEY INT, vol. 67, 2005, pages 404 - 419, XP002373456, DOI: doi:10.1111/j.1523-1755.2005.67097.x
CARAMORI ML; KIM Y; HUANG C ET AL.: "Cellular basis of diabetic nephropathy: 1. Study design and renal structural-functional relationships in patients with long-standing type 1 diabetes", DIABETES, vol. 51, 2002, pages 506 - 13
MOTOHIDE ISONO; MASAKAZU HANEDA; MASAKI TOGAWA; TSUTOMU SHIKANO; SHINNICHI ARAKI; TAKAHIKO NAKAGAWA; TAKERU ISHIDA; KEN INOKI; KEN: "Analysis of Urinary Type IV Collagen in NIDDM Subjects as a Marker for Diabetic Nephropathy", . JAPAN DIAB. SOCI., vol. 39, 1996, pages 599 - 604
ISAO YASHIMA; TOSHIHIDE HIRAYAMA; HIDEO SHIIKI; MASAO KANAUCHI; KAZUHIRO DOHI: "Diagnostic significance of urinary immunoglobulin G in diabetic nephropathy", JPN J NEPHROL, vol. 41, 1999, pages 787 - 96
JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 55, 1997
GOUMANS MJ. ET AL., EMBO J., vol. 21, no. 7, 2 April 2002 (2002-04-02), pages 1743 - 53
CURR DIABETES REV, vol. 7, no. 1, 2011, pages 50
DIABETOLOGIA, vol. 59, 2016, pages 1624
DIABETES, vol. 58, 2009, pages 469
NEPHROL DIAL TRANSPLANT, vol. 30, 2015, pages iv54
NEPHROL DIAL TRANSPLANT, vol. 0, 2016, pages 1
BIOCHEM BIOPHYS RES COMMUN, vol. 360, 2007, pages 772
DIABETES CARE, vol. 32, no. 3, 2009, pages 465
NEPHROL DIAL TRANSPLANT, vol. 29, 2014, pages 119
N ENGL J MED, vol. 369, no. 26, 2013, pages 2492
NEPHROL DIAL TRANSPLANT, vol. 28, 2013, pages 2841
N ENGL J MED, vol. 365, no. 4, 2011, pages 327
AM J PHYSIOL RENAL PHYSIOL, vol. 304, 2013, pages F808
BOJESTIG M; ARNQVIST HJ; HERMANSSON G; KARLBERG BE; LUDVIGSSON J: "Declining incidence of nephropathy in insulin-dependent diabetes mellitus", N ENGL J MED, vol. 330, 1994, pages 15 - 18
PARVING H-H; MAUER M; RITZ E: "Brenner & Rector's The Kidney", 2004, SAUNDERS, ELSEVIER'S HEALTH SCIENCES DEPARTMENT, article "Diabetic nephropathy", pages: 1777 - 1818
DOI T; VLASSARA H; KIRSTEIN M; YAMADA Y; STRIKER GE; STRIKER LJ: "Receptor-specific increase in extracellular matrix production in mouse mesangial cells by advanced glycosylation endproducts is mediated via platelet derived growth factor", PROC NATL ACAD SCI USA, vol. 89, 1992, pages 2873 - 2877
ABE H; MATSUBARA T; IEHARA N ET AL.: "Type IV collagen is transcriptionally regulated by Smadl under advanced glycation end product (AGE) stimulation", J BIOL CHEM, vol. 279, 2004, pages 14201 - 14206, XP002984232, DOI: doi:10.1074/jbc.M310427200
MATSUBARA T; ABE H; ARAI H ET AL.: "Expression of Smadl is directly associated with glomerulosclerosis in diabetic nephropathy", LAB INVEST, vol. 86, 2006, pages 357 - 68
MIMA A; ARAI H; MATSUBARA T ET AL.: "Urinary Smadl is a novel marker to predict later onset of mesangial matrix expansion in diabetic nephropathy", DIABETES, vol. 57, 2008, pages 1712 - 22
MIMA A; MATSUBARA T; ARAI H ET AL.: "Angiotensin II-dependent Src and Smad 1 signaling pathway is crucial for the development of diabetic nephropathy", LAB INVEST, vol. 86, 2006, pages 927 - 939
OHASHI S; ABE H; TAKAHASHI T ET AL.: "Advanced glycation end products increase collagen-specific chaperone protein in mouse diabetic nephropathy", J BIOL CHEM, vol. 279, 2004, pages 19816 - 23
TAKAHASHI T; ABE H; ARAI H ET AL.: "Activation of STAT3/Smadl is a key signaling pathway for progression to glomerulosclerosis in experimental glomerulonephritis", J BIOL CHEM, vol. 280, 2005, pages 7100 - 7106, XP055116802, DOI: doi:10.1074/jbc.M411064200
TOMINAGA T; ABE H; UEDA O ET AL.: "Activation of BMP4 signaling leads to glomerulosclerosis that mimics diabetic nephropathy", J BIOL CHEM, vol. 286, 2011, pages 20109 - 20116
KISHI S; ABE H; AKIYAMA H ET AL.: "Sox9 protein induces a chondrogenic phenotype of mesangial cells and contributes to advanced diabetic nephropathy", J BIOL CHEM, vol. 286, 2011, pages 32162 - 32169
ABE H; TOMINAGA T; MATSUBARA T ET AL.: "Scleraxis modulates bone morphogenetic protein 4 (BMP4)-Smadl-smooth muscle a-actin (SMA) signal transduction in diabetic nephropathy", J BIOL CHEM, vol. 287, 2012, pages 20430 - 42
MATSUBARA T; ARAKI M; ABE H ET AL.: "Bone morphogenetic protein 4 and Smadl mediate extracellular matrix production in the development of diabetic nephropathy", DIABETES, vol. 64, no. 8, 2015, pages 2978 - 90
DECKERT T; FELDT-RASMUSSEN B; DJURUP R ET AL.: "Glomerular size and charge selectivity in insulin-dependent diabetes mellitus", KIDNEY INT, vol. 33, 1988, pages 101 - 106
MELVIN T; KIM Y; MICHAEL AF: "Selective binding IgG4 and other negatively charged plasma proteins in normal and diabetic human kidneys", AM J PATHOL, vol. 115, 1984, pages 443 - 446
MORIYA T; TSUCHIYA A; OKIZAKI S ET AL.: "Glomerular hyperfiltration/ increased glomerular filtration surface are associated with renal function decline in normo- and microalbuminuric type 2 diabetes", KIDNEY INT, vol. 81, 2012, pages 486 - 493
MORIYA T; MORIYA R; YAJIMA Y ET AL.: "Urinary albumin as an indicator of diabetic nephropathy lesions in Japanese type 2 diabetic patients", NEPHRON, vol. 91, 2002, pages 292 - 299
MATSUO S; IMAI E; HORIO M ET AL.: "Revised equations for estimated GFR from serum creatinine in Japan", AM J KIDNEY DIS, vol. 53, 2009, pages 982 - 92
YAMAMOTO Y; KATO I; DOI T ET AL.: "Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice", J CLIN INVEST, vol. 108, 2001, pages 261 - 268, XP002983725, DOI: doi:10.1172/JCI200111771
CHAVERS BM; BILOUS RW; ELLIS EN ET AL.: "Glomerular lesions and urinary albumin excretion in type I diabetes without overt proteinuria", N ENGL J MED, vol. 320, 1989, pages 966 - 970
FIORETTO P; STEFFES MW; MAUER M: "Glomerular structure in nonproteinuric IDDM patients with various levels of albuminuria", DIABETES, vol. 43, 1994, pages 1358 - 1364
JENSEN EB; GUNDERSEN HJ; OSTERBY R: "Determination of membrane thickness distribution from orthogonal intercepts", J MICROSC, vol. 115, 1979, pages 19 - 33
UNO S; KINOSHITA Y; AZUMA Y ET AL.: "Antitumor activity of a monoclonal antibody against CD47 in xenograft models of human leukemia", ONCOL REP, vol. 17, 2007, pages 1189 - 1194, XP055127957, DOI: doi:10.3892/or.17.5.1189
CARAMORI ML; FIORETTO P; MAUER M: "The need for early predictors of diabetic nephropathy risk: is albumin excretion rate sufficient?", DIABETES, vol. 49, 2000, pages 1399 - 408
DE BOER IH; RUE TC; HALL YN ET AL.: "Temporal trends in the prevalence of diabetic kidney disease in the United States", JAMA, vol. 305, 2011, pages 2532 - 9
ADLER AI; STEVENS RJ; MANLEY SE ET AL.: "Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64", KIDNEY INT, vol. 63, 2003, pages 225 - 32
CARAMORI ML; PARKS A; MAUER M: "Renal lesions predict progression of diabetic nephropathy in type 1 diabetes", JAM SOC NEPHROL, vol. 24, 2013, pages 1175 - 81
MORIYA T; TANAKA K; HOSAKA T ET AL.: "Renal structure as an indicator for development of albuminuria in normo- and microalbuminuric type 2 diabetic patients", DIABETES RES CLIN PRACT, vol. 82, 2008, pages 298 - 304, XP025712120, DOI: doi:10.1016/j.diabres.2008.08.015
See also references of EP 3521827A4
NEGISHI, KIYOHIKO: "Urinary Total IgG and IgG4 Excretion in Non-Insulin-Dependent Diabetes Mellitus. Using a Sensitive Total IgG and IgG4 Assay.:Using a Sensitive Total IgG and IgG4 Assay", JOURNAL OF THE JAPAN DIABETES SOCIETY, vol. 35, no. 12, 1 December 1992 (1992-12-01), pages 1007 - 1011, XP055597288, DOI: 10.11213/tonyobyo1958.35.1007
MORANO S.: "URINARY IGGR4 AN ADDITIONAL PARAMETER IN CHARACTERIZED PATIENTS WITH STAGE III DIABETIC NEPHROPATHY", DIABETOLOGIA, vol. 30, no. 7, 1987, pages 559A 384, XP009514427, ISSN: 0012-186X
TOMINAGA, SHINYA: "Usefulness of Smadl in Urine in Diagnosis of Early-stage Nephropathy", JAPANESE JOURNAL OF MEDICAL TECHNOLOGY, vol. 54, no. 4, 25 April 2005 (2005-04-25), TOMINAGA, Shinya, pages 642 (344), XP009515680
TORFFVIT 0.: "Size and charge selectivity of the glomerular filter in patients with insulin-dependent diabetes mellitus: urinary immunogloblins and glycosaminoglycans", NEPHRON, vol. 83, no. 4, 1999, pages 301 - 307, XP009515263, DOI: 10.1159/000045421
MORANO S.: "The selective eliminations of anionic immunogloblins as a parameter of kidney damage in debetes and diabetic pregnancy", THE JOURNAL OF DEABETIC COMPLICATIONS, vol. 2, no. 1, 1988, pages 2 - 4, XP001087989
ISAO YASHIMA: "Diagnostic significance of urinary immunoglobulin G in diabetic nephropathy", JAPANESE JOURNAL OF NEPHROLOGY, vol. 41, no. 8, 25 December 1999 (1999-12-25), pages 787 - 796, XP009515265, DOI: 10.14842/jpnjnephrol1959.41.787
MOTOHIDE ISONO; MASAKAZU HANEDA; MASAKI TOGAWA; TSUTOMU SHIKANO; SHINNICHI ARAKI; TAKAHIKO NAKAGAWA; TAKERU ISHIDA; KEN INOKI; KEN: "Analysis of Urinary Type IV Collagen in NIDDM Subjects as a Marker for Diabetic Nephropathy", J. JAPAN DIAB. SOCI., vol. 39, 1996, pages 599 - 604
YASUHIKO IEKI; EISUKE TAKAZAKURA: "Significance of Measurement of Urinary Type IV Collagen as a Predictor of Progress of Early-Stage Diabetic Nephropathy", J. JAPAN DIAB. SOCI., vol. 42, 1999, pages 859 - 862
KIYOHIKO NEGISHI; SATOMI SHIBASAKI; YASUAKI ISHIMARU ET AL.: "Total Urinary IgG and IgG4 Excretion in Non-Insulin-Dependent Diabetes Mellitus - Using a Sensitive Total IgG and IgG4 Assay", J. JAPAN DIAB. SOC., vol. 35, 1992, pages 1007 - 1011
ISAO YASHIMA; TOSHIHIDE HIRAYAMA; HIDEO SHIIKI; MASAO KANAUCHI; KAZUHIRO DOHI: "Diagnostic significance of urinary immunoglobulin G in diabetic nephropathy", JPN J NEPHROL, vol. 41, 1999, pages 787 - 796
KROLEWSKI M; EGGERS PW; WARRAM JH: "Magnitude of end-stage renal disease in IDDM: a 35 year follow-up study", KIDNEY INT, vol. 50, 1996, pages 2041 - 2046
BOJESTIG M; AMQVIST HJ; HERMANSSON G; KARLBERG BE; LUDVIGSSON J: "Declining incidence of nephropathy in insulin-dependent diabetes mellitus", N ENGL J MED, vol. 330, 1994, pages 15 - 18
PARVING H-H; MAUER M; RITZ E: "Diabetic nephropathy", 2004, SAUNDERS, ELSEVIER'S HEALTH SCIENCES DEPARTMENT, pages: 1777 - 1818
MAUER SM; STEFFES MW; ELLIS EN; SUTHERLAND DE; BROWN DM; GOETZ FC: "Structural-functional relationships in diabetic nephropathy", J CLIN INVEST, vol. 74, 1984, pages 1143 - 1155
KRIZ W; LEHIR M: "Pathways to nephron loss starting from glomerular disease- Insights from animal models", KIDNEY INT, vol. 67, 2005, pages 404 - 419, XP002373456, DOI: doi:10.1111/j.1523-1755.2005.67097.x
CARAMORI ML; KIM Y; HUANG C ET AL.: "Cellular basis of diabetic nephropathy: 1. Study design and renal structural-functional relationships in patients with long-standing type 1 diabetes", DIABETES, vol. 51, 2002, pages 506 - 13
MOTOHIDE ISONO; MASAKAZU HANEDA; MASAKI TOGAWA; TSUTOMU SHIKANO; SHINNICHI ARAKI; TAKAHIKO NAKAGAWA; TAKERU ISHIDA; KEN INOKI; KEN: "Analysis of Urinary Type IV Collagen in NIDDM Subjects as a Marker for Diabetic Nephropathy", . JAPAN DIAB. SOCI., vol. 39, 1996, pages 599 - 604
ISAO YASHIMA; TOSHIHIDE HIRAYAMA; HIDEO SHIIKI; MASAO KANAUCHI; KAZUHIRO DOHI: "Diagnostic significance of urinary immunoglobulin G in diabetic nephropathy", JPN J NEPHROL, vol. 41, 1999, pages 787 - 96
JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 55, 1997
GOUMANS MJ. ET AL., EMBO J., vol. 21, no. 7, 2 April 2002 (2002-04-02), pages 1743 - 53
CURR DIABETES REV, vol. 7, no. 1, 2011, pages 50
DIABETOLOGIA, vol. 59, 2016, pages 1624
DIABETES, vol. 58, 2009, pages 469
NEPHROL DIAL TRANSPLANT, vol. 30, 2015, pages iv54
NEPHROL DIAL TRANSPLANT, vol. 0, 2016, pages 1
BIOCHEM BIOPHYS RES COMMUN, vol. 360, 2007, pages 772
DIABETES CARE, vol. 32, no. 3, 2009, pages 465
NEPHROL DIAL TRANSPLANT, vol. 29, 2014, pages 119
N ENGL J MED, vol. 369, no. 26, 2013, pages 2492
NEPHROL DIAL TRANSPLANT, vol. 28, 2013, pages 2841
N ENGL J MED, vol. 365, no. 4, 2011, pages 327
AM J PHYSIOL RENAL PHYSIOL, vol. 304, 2013, pages F808
BOJESTIG M; ARNQVIST HJ; HERMANSSON G; KARLBERG BE; LUDVIGSSON J: "Declining incidence of nephropathy in insulin-dependent diabetes mellitus", N ENGL J MED, vol. 330, 1994, pages 15 - 18
PARVING H-H; MAUER M; RITZ E: "Brenner & Rector's The Kidney", 2004, SAUNDERS, ELSEVIER'S HEALTH SCIENCES DEPARTMENT, article "Diabetic nephropathy", pages: 1777 - 1818
DOI T; VLASSARA H; KIRSTEIN M; YAMADA Y; STRIKER GE; STRIKER LJ: "Receptor-specific increase in extracellular matrix production in mouse mesangial cells by advanced glycosylation endproducts is mediated via platelet derived growth factor", PROC NATL ACAD SCI USA, vol. 89, 1992, pages 2873 - 2877
ABE H; MATSUBARA T; IEHARA N ET AL.: "Type IV collagen is transcriptionally regulated by Smadl under advanced glycation end product (AGE) stimulation", J BIOL CHEM, vol. 279, 2004, pages 14201 - 14206, XP002984232, DOI: doi:10.1074/jbc.M310427200
MATSUBARA T; ABE H; ARAI H ET AL.: "Expression of Smadl is directly associated with glomerulosclerosis in diabetic nephropathy", LAB INVEST, vol. 86, 2006, pages 357 - 68
MIMA A; ARAI H; MATSUBARA T ET AL.: "Urinary Smadl is a novel marker to predict later onset of mesangial matrix expansion in diabetic nephropathy", DIABETES, vol. 57, 2008, pages 1712 - 22
MIMA A; MATSUBARA T; ARAI H ET AL.: "Angiotensin II-dependent Src and Smad 1 signaling pathway is crucial for the development of diabetic nephropathy", LAB INVEST, vol. 86, 2006, pages 927 - 939
OHASHI S; ABE H; TAKAHASHI T ET AL.: "Advanced glycation end products increase collagen-specific chaperone protein in mouse diabetic nephropathy", J BIOL CHEM, vol. 279, 2004, pages 19816 - 23
TAKAHASHI T; ABE H; ARAI H ET AL.: "Activation of STAT3/Smadl is a key signaling pathway for progression to glomerulosclerosis in experimental glomerulonephritis", J BIOL CHEM, vol. 280, 2005, pages 7100 - 7106, XP055116802, DOI: doi:10.1074/jbc.M411064200
TOMINAGA T; ABE H; UEDA O ET AL.: "Activation of BMP4 signaling leads to glomerulosclerosis that mimics diabetic nephropathy", J BIOL CHEM, vol. 286, 2011, pages 20109 - 20116
KISHI S; ABE H; AKIYAMA H ET AL.: "Sox9 protein induces a chondrogenic phenotype of mesangial cells and contributes to advanced diabetic nephropathy", J BIOL CHEM, vol. 286, 2011, pages 32162 - 32169
ABE H; TOMINAGA T; MATSUBARA T ET AL.: "Scleraxis modulates bone morphogenetic protein 4 (BMP4)-Smadl-smooth muscle a-actin (SMA) signal transduction in diabetic nephropathy", J BIOL CHEM, vol. 287, 2012, pages 20430 - 42
MATSUBARA T; ARAKI M; ABE H ET AL.: "Bone morphogenetic protein 4 and Smadl mediate extracellular matrix production in the development of diabetic nephropathy", DIABETES, vol. 64, no. 8, 2015, pages 2978 - 90
DECKERT T; FELDT-RASMUSSEN B; DJURUP R ET AL.: "Glomerular size and charge selectivity in insulin-dependent diabetes mellitus", KIDNEY INT, vol. 33, 1988, pages 101 - 106
MELVIN T; KIM Y; MICHAEL AF: "Selective binding IgG4 and other negatively charged plasma proteins in normal and diabetic human kidneys", AM J PATHOL, vol. 115, 1984, pages 443 - 446
MORIYA T; TSUCHIYA A; OKIZAKI S ET AL.: "Glomerular hyperfiltration/ increased glomerular filtration surface are associated with renal function decline in normo- and microalbuminuric type 2 diabetes", KIDNEY INT, vol. 81, 2012, pages 486 - 493
MORIYA T; MORIYA R; YAJIMA Y ET AL.: "Urinary albumin as an indicator of diabetic nephropathy lesions in Japanese type 2 diabetic patients", NEPHRON, vol. 91, 2002, pages 292 - 299
MATSUO S; IMAI E; HORIO M ET AL.: "Revised equations for estimated GFR from serum creatinine in Japan", AM J KIDNEY DIS, vol. 53, 2009, pages 982 - 92
YAMAMOTO Y; KATO I; DOI T ET AL.: "Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice", J CLIN INVEST, vol. 108, 2001, pages 261 - 268, XP002983725, DOI: doi:10.1172/JCI200111771
CHAVERS BM; BILOUS RW; ELLIS EN ET AL.: "Glomerular lesions and urinary albumin excretion in type I diabetes without overt proteinuria", N ENGL J MED, vol. 320, 1989, pages 966 - 970
FIORETTO P; STEFFES MW; MAUER M: "Glomerular structure in nonproteinuric IDDM patients with various levels of albuminuria", DIABETES, vol. 43, 1994, pages 1358 - 1364
JENSEN EB; GUNDERSEN HJ; OSTERBY R: "Determination of membrane thickness distribution from orthogonal intercepts", J MICROSC, vol. 115, 1979, pages 19 - 33
UNO S; KINOSHITA Y; AZUMA Y ET AL.: "Antitumor activity of a monoclonal antibody against CD47 in xenograft models of human leukemia", ONCOL REP, vol. 17, 2007, pages 1189 - 1194, XP055127957, DOI: doi:10.3892/or.17.5.1189
CARAMORI ML; FIORETTO P; MAUER M: "The need for early predictors of diabetic nephropathy risk: is albumin excretion rate sufficient?", DIABETES, vol. 49, 2000, pages 1399 - 408
DE BOER IH; RUE TC; HALL YN ET AL.: "Temporal trends in the prevalence of diabetic kidney disease in the United States", JAMA, vol. 305, 2011, pages 2532 - 9
ADLER AI; STEVENS RJ; MANLEY SE ET AL.: "Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64", KIDNEY INT, vol. 63, 2003, pages 225 - 32
CARAMORI ML; PARKS A; MAUER M: "Renal lesions predict progression of diabetic nephropathy in type 1 diabetes", JAM SOC NEPHROL, vol. 24, 2013, pages 1175 - 81
MORIYA T; TANAKA K; HOSAKA T ET AL.: "Renal structure as an indicator for development of albuminuria in normo- and microalbuminuric type 2 diabetic patients", DIABETES RES CLIN PRACT, vol. 82, 2008, pages 298 - 304, XP025712120, DOI: doi:10.1016/j.diabres.2008.08.015
See also references of EP 3521827A4
Attorney, Agent or Firm:
MAYAMA, Setsuko et al. (JP)
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